Yang Xiuyan, Chen Xichen, Ji Chunhui, Zhang Liang, Yan Chuanbin, Lin Bin, Du Juan, Wang Zhen
1School of Mechanical Engineering, Tianjin University, Tianjin, China.
2Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.
Acta Bioeng Biomech. 2025 Jan 28;26(2):59-71. doi: 10.37190/abb-02415-2024-03. Print 2024 Jun 1.
: This study aimed to explore how the microarchitectural features of lacunae and perilacunar zones impact the biomechanics of microdamage accumulation in cortical bone, crucial for understanding bone disorders' pathogenesis and developing preventive measures. : Utilizing the phase field finite element method, the study analyzed three bone unit models with varying microarchitecture: one without lacunae, one with lacunae and one including perilacunar zones, to assess their effects on cortical bone's biomechanical properties. : The presence of lacunae was found to increase microcrack initiation risk, acting as nucleation points and accelerating microcrack propagation. Proximity to Haversian canals exacerbated stress concentration, speeding microdamage progression. Conversely, perilacunar zones mitigated both initiation and propagation. An elevated critical energy release rate correlated with slower crack growth and reduced damage severity. : The research sheds light on the intricate mechanisms governing microcrack behavior in compact bone, highlighting the significant role of bone's microarchitectural features in its biomechanical response to microdamage. These insights are valuable for the development of strategies to prevent and treat bone-related disorders.
本研究旨在探讨骨陷窝和陷窝周围区域的微观结构特征如何影响皮质骨微损伤积累的生物力学，这对于理解骨疾病的发病机制和制定预防措施至关重要。利用相场有限元方法，该研究分析了三种具有不同微观结构的骨单元模型：一种没有骨陷窝，一种有骨陷窝，一种包括陷窝周围区域，以评估它们对皮质骨生物力学性能的影响。研究发现，骨陷窝的存在会增加微裂纹起始风险，充当形核点并加速微裂纹扩展。靠近哈弗斯管会加剧应力集中，加速微损伤进展。相反，陷窝周围区域减轻了起始和扩展。临界能量释放率升高与裂纹生长较慢和损伤严重程度降低相关。该研究揭示了致密骨中微裂纹行为的复杂机制，突出了骨微观结构特征在其对微损伤的生物力学反应中的重要作用。这些见解对于预防和治疗骨相关疾病的策略的开发具有重要价值。
