Choi Hye Rin, Chang Yoosoo, Kang Danbee, Lee Jiseon, Jang Yoonyoung, Kim Hoon, Ryu Seungho, Park Hyun-Young, Cho Juhee
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
National Institute of Health, Cheongju, Republic of Korea.
Menopause. 2025 Apr 1;32(4):337-345. doi: 10.1097/GME.0000000000002501. Epub 2025 Jan 28.
We examined the health-related quality of life (HRQoL) during menopause transition (MT) among middle-aged Korean women.
This cross-sectional study comprised 2,290 middle-aged women who completed web-based questionnaires between 2020 and 2022. Based on self-reported menstrual cycle patterns, menopause status was classified as premenopausal, early or late transition, or postmenopausal. HRQoL was assessed using the Patient-Reported Outcomes Measurement Information system, with all 29 items scored using a T-score metric. Multiple linear regression analyses were performed to investigate whether HRQoL varied based on MT stages. Antimüllerian hormone levels were used as an objective measure instead of self-reported menstrual status in the sensitivity analysis. Logistic regression models were used to estimate the prevalence ratios for moderate or severe HRQoL symptoms across menopausal stages.
The mean T-scores for anxiety, depression, and pain interference and intensity were significantly higher with advancing menopausal stage. Anxiety, depression, sleep disturbances, pain interference, and intensity were significantly and linearly positively correlated with MT stages after adjusting for potential confounders. Physical function significantly worsened in the late transition stage compared with premenopausal status ( β = -1.51 [95% CI, -2.72 to -0.31] in late MT and β = -1.92 [95% CI, -3.46 to -0.37] in postmenopause, P for trend = 0.007). However, no significant trends were observed in the sensitivity analysis using antimüllerian hormone levels. Women with moderate or severe symptoms in all domains except physical function had significantly higher prevalence ratios according to MT.
Overall HRQoL was lower with advancing menopausal stages. All symptoms should be monitored to control early transition symptoms. Thus, women undergoing MT should consistently assess and manage not only menopausal symptoms but also the overall quality of their health to prevent both menopause-specific and nonspecific conditions and their consequences.
我们研究了韩国中年女性绝经过渡（MT）期间与健康相关的生活质量（HRQoL）。
这项横断面研究纳入了2290名中年女性，她们在2020年至2022年间完成了基于网络的问卷调查。根据自我报告的月经周期模式，绝经状态分为绝经前、早期或晚期过渡或绝经后。使用患者报告结局测量信息系统评估HRQoL，所有29项均采用T评分指标评分。进行多元线性回归分析，以研究HRQoL是否因MT阶段而异。在敏感性分析中，使用抗苗勒管激素水平作为客观指标，而非自我报告的月经状态。使用逻辑回归模型估计各绝经阶段中度或重度HRQoL症状的患病率比值。
随着绝经阶段的推进，焦虑、抑郁、疼痛干扰和强度的平均T评分显著升高。在调整潜在混杂因素后，焦虑、抑郁、睡眠障碍、疼痛干扰和强度与MT阶段显著且呈线性正相关。与绝经前状态相比，晚期过渡阶段的身体功能显著恶化（晚期MT时β=-1.51[95%CI，-2.72至-0.31]，绝经后β=-1.92[95%CI，-3.46至-0.37]，趋势P=0.007）。然而，在使用抗苗勒管激素水平的敏感性分析中未观察到显著趋势。除身体功能外，所有领域有中度或重度症状的女性根据MT的患病率比值显著更高。
随着绝经阶段的推进，总体HRQoL较低。应监测所有症状以控制早期过渡症状。因此，处于MT的女性应持续评估和管理不仅是绝经症状，还有她们的整体健康质量，以预防绝经特异性和非特异性疾病及其后果。
