Kruit P J, van Balen A T, Stilma J S
Doc Ophthalmol. 1985 Jan 31;59(1):33-9. doi: 10.1007/BF00162007.
One patient with the clinical diagnosis of Wegener's disease suffered from bilateral progressive uveitis and corneal melting which did not react to steroid and immunosuppressive therapy. Cyclosporin A produced dramatic improvement within 5 days, of both the uveitis and the corneal melting. The second patient had severe progressive corneal melting and scleral melting in one eye, which did not react to corticosteroid therapy or grafting of the defects. The corneal melting stopped completely on cyclosporin A therapy for two months. Gum hypertrophy was only seen as a side effect of cyclosporin A therapy in one patient, no severe side effects such as kidney or liver dysfunction were noted.
一名临床诊断为韦格纳氏病的患者患有双侧进行性葡萄膜炎和角膜溶解，对类固醇和免疫抑制治疗无反应。环孢素A在5天内使葡萄膜炎和角膜溶解均有显著改善。第二名患者一只眼睛出现严重的进行性角膜溶解和巩膜溶解，对皮质类固醇治疗或缺损移植均无反应。使用环孢素A治疗两个月后，角膜溶解完全停止。仅一名患者出现牙龈增生作为环孢素A治疗的副作用，未观察到诸如肾或肝功能障碍等严重副作用。
