Timmer-Murillo Sydney C, Mowrer Alyssa, Rundell Maddie R, Jazinski-Chambers Kelly, Piña Isela, deRoon-Cassini Terri A, Wagner Amy J
Division of Trauma and Acute Care Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
Division of Pediatric Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
Am J Perinatol. 2025 Aug;42(11):1461-1468. doi: 10.1055/a-2508-2490. Epub 2025 Jan 28.
Pregnant women face heightened vulnerability to mental health disorders (MHDs). There remains a lack of data during the antenatal period, particularly for high-risk subpopulations such as those with fetal anomalies. Understanding the psychological impact of women receiving a fetal anomaly diagnosis is crucial, as it can lead to MHDs. Additionally, maternal stress due to such diagnoses can have adverse effects on short- and long-term health outcomes for both the mother and the child. This study aimed to address the gap in knowledge regarding prenatal MHDs in women with fetal anomalies by characterizing maternal peripartum psychological health and identifying factors related to MHDs.Women diagnosed with fetal anomalies ( = 110) were recruited from a tertiary fetal care center and completed surveys assessing resilience, anxiety, depression, and posttraumatic stress symptoms (PTSs). Demographic characteristics were also collected and analyzed. Multiple regression analyses were conducted to explore associations between demographic variables and mental health outcomes.Participants endorsed elevated depressive symptoms (45%), anxiety (43%), and PTSs (39%). Private insurance and relationship status were positively associated, and resilience was negatively associated, with depression and anxiety levels. Maternal perception of diagnostic severity correlated with increased depressive symptoms and PTSs, whereas physician ratings of diagnostic severity did not.The findings underscore the prevalence of MHD among pregnant women with fetal anomalies and emphasize the importance of assessing maternal perception of severity in predicting mental health outcomes. Identifying risk factors like insurance status and relationship status suggests avenues for targeted screening and intervention. Multidisciplinary collaboration is essential for implementing effective strategies to address peripartum psychopathology related to fetal anomalies and improve overall maternal and fetal health. · Pregnant women with fetal anomalies face poor mental health.. · Resilience is negatively related to poor mental health.. · Perception of severity impacts mental health symptoms..
孕妇面临心理健康障碍（MHDs）的更高易感性。产前期间的数据仍然匮乏，尤其是对于胎儿异常等高危亚人群。了解接受胎儿异常诊断的女性的心理影响至关重要，因为这可能导致心理健康障碍。此外，此类诊断导致的母亲压力会对母亲和孩子的短期和长期健康结果产生不利影响。本研究旨在通过描述孕产妇围产期心理健康状况并确定与心理健康障碍相关的因素，来填补胎儿异常女性产前心理健康障碍方面的知识空白。
从一家三级胎儿护理中心招募了被诊断为胎儿异常的女性（n = 110），她们完成了评估复原力、焦虑、抑郁和创伤后应激症状（PTSs）的调查。还收集并分析了人口统计学特征。进行多元回归分析以探索人口统计学变量与心理健康结果之间的关联。
参与者认可抑郁症状（45%）、焦虑（43%）和创伤后应激症状（39%）有所增加。私人保险和关系状况与抑郁和焦虑水平呈正相关，而复原力与之呈负相关。母亲对诊断严重性的感知与抑郁症状和创伤后应激症状的增加相关，而医生对诊断严重性的评级则不然。
研究结果强调了胎儿异常孕妇中心理健康障碍的普遍性，并强调了在预测心理健康结果时评估母亲对严重性感知的重要性。识别保险状况和关系状况等风险因素为有针对性的筛查和干预提供了途径。多学科合作对于实施有效策略以解决与胎儿异常相关的围产期精神病理学问题并改善母婴整体健康至关重要。· 患有胎儿异常的孕妇心理健康状况不佳。· 复原力与不良心理健康呈负相关。· 对严重性的感知影响心理健康症状。
