降胆固醇药物：考来烯胺和果胶对大鼠相对疗效的比较

Hypocholesterolemic agents: a comparison of the relative effectiveness of cholestyramine and pectin in rats.

作者信息

Baig M M, Burgin C W, Cerda J J

出版信息

Drug Nutr Interact. 1985;3(2):109-13.

Abstract

Studies were carried out to evaluate the comparative effectiveness of cholestyramine and pectin as hypocholesterolemic agents. Circulating levels of serum cholesterol and lipoprotein-associated cholesterol were measured in rats fed high cholesterol diet supplemented with either cholestyramine or pectin. When compared with controls, a significant decrease in the level of total cholesterol was observed in rats fed either cholestyramine or pectin (p less than 0.001, 43% reduction in cholesterol, and p less than 0.04, 25% reduction in cholesterol, respectively) and this was due exclusively to the lowering of low density lipoprotein. Further statistical evaluation of data revealed no significant difference between the cholesterol levels of rats fed either cholestyramine or pectin (p greater than 0.07). The data acquired in this study suggest that both cholestyramine and pectin are comparable and effective hypocholesterolemic agents and the observed hypocholesterolemic effect of these agents is mediated through lowering of cholesterol associated with the low density lipoprotein.

摘要

开展了多项研究以评估消胆胺和果胶作为降胆固醇药物的相对疗效。在喂食添加了消胆胺或果胶的高胆固醇饮食的大鼠中，测量血清胆固醇和脂蛋白相关胆固醇的循环水平。与对照组相比，喂食消胆胺或果胶的大鼠总胆固醇水平显著降低（分别为p<0.001，胆固醇降低43%；p<0.04，胆固醇降低25%），这完全是由于低密度脂蛋白降低所致。对数据的进一步统计评估显示，喂食消胆胺或果胶的大鼠的胆固醇水平之间无显著差异（p>0.07）。本研究获得的数据表明，消胆胺和果胶都是相当且有效的降胆固醇药物，并且观察到这些药物的降胆固醇作用是通过降低与低密度脂蛋白相关的胆固醇来介导的。