促红细胞生成素α对未接触过相关物质的雌性大鼠有显著的抗焦虑作用。
Epoetin alfa has a potent anxiolytic effect on naive female rats.
作者信息
Çalışkan Hasan, Koçak Seda, Güneş Emel
机构信息
Department of Physiology, Balıkesir University Medicine Faculty, Balıkesir, Turkey.
Department of Physiology, Kırşehir Ahi Evran University Medicine Faculty, Kırşehir, Turkey.
出版信息
BMC Pharmacol Toxicol. 2025 Jan 28;26(1):18. doi: 10.1186/s40360-025-00845-y.
BACKGROUND
Epoetin alfa is a derivative of the erythropoietin hormone. This study aims to investigate the epoetin alfa effect on anxiety-like behaviors.
METHODS
Adult female Wistar Albino rats were divided into Control (n = 8), 1000 U Epoetien alfa, and 2000 U Epoetien alpha. Epoetin alfa was administered intraperitoneally once a week for 4 weeks. The animals were then subjected to open field test, elevated plus maze, light-dark box, and the behaviors were video recorded.
RESULTS
Epoetin alfa significantly reduced anxiety-like behaviors in both low- and high-dose groups in a dose-independent manner. This anxiolytic effect was seen in all three anxiety tests. Further, exploratory behaviors such as unsupported rearing and head-dipping behaviors increased with the application of Epoetin alfa. This protocol did not alter locomotor activity.
CONCLUSION
The present study found beneficial effects of epoetin alfa on behaviors. Further studies on the effect of derivatives of erythropoietin hormone on anxiety-like behaviors are needed.
背景
促红细胞生成素α是促红细胞生成素激素的衍生物。本研究旨在探讨促红细胞生成素α对焦虑样行为的影响。
方法
将成年雌性Wistar白化大鼠分为对照组（n = 8）、1000 U促红细胞生成素α组和2000 U促红细胞生成素α组。促红细胞生成素α每周腹腔注射一次，共4周。然后对动物进行旷场试验、高架十字迷宫试验、明暗箱试验，并对行为进行视频记录。
结果
促红细胞生成素α在低剂量组和高剂量组均以剂量非依赖性方式显著降低焦虑样行为。在所有三项焦虑试验中均观察到这种抗焦虑作用。此外，随着促红细胞生成素α的应用，诸如无支撑站立和探头行为等探索行为增加。该方案未改变运动活性。
结论
本研究发现促红细胞生成素α对行为有有益影响。需要进一步研究促红细胞生成素激素衍生物对焦虑样行为的影响。
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