苯妥英对猫血清及器官中锌和铜浓度的影响。

The effects of phenytoin on serum and organ concentrations of zinc and copper in cat.

作者信息

Palm R, Hänström L, Hallmans G, Winblad B

出版信息

Epilepsia. 1985 Mar-Apr;26(2):184-8. doi: 10.1111/j.1528-1157.1985.tb05403.x.

DOI:10.1111/j.1528-1157.1985.tb05403.x

Abstract

The effects of phenytoin (PHT) on zinc (Zn) and copper (Cu) concentrations in serum and different organs have been studied in cats. Five cats were treated with PHT 5 mg/kg body weight each day. Increased serum concentrations of Zn and Cu were found after 12 weeks of treatment. Increased Zn concentrations were found in the kidney and increased Cu concentrations in the liver and kidney. There wee signs of fatty degeneration of the liver. It is postulated that the drug acts as a chelator of the minerals and enhances their absorption from the intestine. A Cu accumulation may occur during PHT treatment.

摘要

已在猫身上研究了苯妥英（PHT）对血清及不同器官中锌（Zn）和铜（Cu）浓度的影响。五只猫每天接受5毫克/千克体重的PHT治疗。治疗12周后，血清中Zn和Cu的浓度升高。肾脏中Zn浓度升高，肝脏和肾脏中Cu浓度升高。有肝脏脂肪变性的迹象。据推测，该药物作为矿物质的螯合剂，可增强其从肠道的吸收。在PHT治疗期间可能会发生Cu蓄积。