Malsch Rachel M, Tessem Rachael B, Dalvin Lauren A
Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA.
Semin Ophthalmol. 2025 Aug;40(6):508-517. doi: 10.1080/08820538.2025.2457043. Epub 2025 Jan 28.
Standardized data collection is needed to improve research for rare diseases. In this manuscript, we describe our experience establishing the Prospective Ocular Tumor Study (POTS).
The ongoing POTS captures all patients with an ocular tumor seen on the Ocular Oncology Service at Mayo Clinic Rochester and collects patient demographics, tumor features, treatment, and outcomes. This manuscript reports data collected from July 2019-July 2024.
During a 5-year time period, 1,766 patients enrolled in the database, with 975 (55%) females, 1,732 (98%) white race, and mean age 61.5 years. The most frequent tumor types were choroidal melanoma ( = 610 [34%]), choroidal nevus ( = 575 [32%]), iris nevus ( = 95 [5.3%]), iris melanoma ( = 46 [2.6%]), and vitreoretinal lymphoma ( = 46 [2.6%]).
The POTS is a valuable source of detailed, longitudinal data on rare ocular tumors. Expanding standardized data collection across multiple centers will facilitate improved outcomes research in ocular oncology.
需要标准化的数据收集来改善对罕见病的研究。在本手稿中，我们描述了建立前瞻性眼肿瘤研究（POTS）的经验。
正在进行的POTS纳入了在梅奥诊所罗切斯特分校眼肿瘤服务部门就诊的所有眼肿瘤患者，并收集患者人口统计学信息、肿瘤特征、治疗情况和结果。本手稿报告了2019年7月至2024年7月收集的数据。
在5年时间里，1766名患者纳入数据库，其中女性975名（55%），白人1732名（98%），平均年龄61.5岁。最常见的肿瘤类型为脉络膜黑色素瘤（n = 610 [34%]）、脉络膜痣（n = 575 [32%]）、虹膜痣（n = 95 [5.3%]）、虹膜黑色素瘤（n = 46 [2.6%]）和玻璃体视网膜淋巴瘤（n = 46 [2.6%]）。
POTS是关于罕见眼肿瘤详细纵向数据的宝贵来源。在多个中心扩大标准化数据收集将有助于改善眼肿瘤学的疗效研究。
