Dhingra Shaurya, Raman Puneet, Ramsaroop Taylor, Harrison Isaiah, Bergsten Tova, Nusbaum Erin, Feldman Lawrence E
University of Illinois College of Medicine, Chicago, IL, United States.
Jesse Brown VA Medical Center, Chicago, IL, United States.
Front Med (Lausanne). 2025 Jan 14;11:1470046. doi: 10.3389/fmed.2024.1470046. eCollection 2024.
Serum levels of the tumor marker CA 19-9 are widely utilized in the diagnosis and monitoring pancreatic and biliary malignancies. However, serum levels of CA 19-9 have also been reportedly elevated in non-malignant conditions. Here, we present the rare case of a 65-year-old woman with a history of gallbladder malignancy who was found to have a new hepatic lesion on surveillance CT with an associated elevation in CA 19-9 to 5,866 U/mL. Drainage of the lesion and treatment with antibiotics resulted in a rapid decline in CA 19-9 levels, indicating that the elevation in CA 19-9 was due to a benign hepatic lesion. We review eight similar reported cases of CA 19-9 elevations due to benign hepatic abscesses, thereby highlighting a need to interpret the tumor marker with caution.
肿瘤标志物CA 19-9的血清水平被广泛用于胰腺和胆道恶性肿瘤的诊断及监测。然而，据报道，在非恶性疾病中CA 19-9的血清水平也会升高。在此，我们报告一例罕见病例，一名65岁有胆囊恶性肿瘤病史的女性，在监测CT上发现肝脏有新病灶，同时CA 19-9升高至5866 U/mL。对病灶进行引流并使用抗生素治疗后，CA 19-9水平迅速下降，表明CA 19-9升高是由良性肝脏病变引起的。我们回顾了八例因良性肝脓肿导致CA 19-9升高的类似报道病例，从而强调了谨慎解读肿瘤标志物的必要性。
