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伪装成肿瘤:表现为肝脓肿的胆囊肿瘤

A Tumor in Disguise: Gallbladder Tumor Presenting as Hepatic Abscesses.

作者信息

Haseeb Ul Rasool Muhammad, Saha Utsow, Sethi Arshia K, Adnan Muhammad, Rabby Nahian

机构信息

Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New York City, USA.

Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New York City, USA.

出版信息

Cureus. 2023 Aug 30;15(8):e44369. doi: 10.7759/cureus.44369. eCollection 2023 Aug.

Abstract

Gallbladder tumors are the most common tumors of the biliary tract. They are rare but clinically aggressive tumors found either as metastatic disease or occasionally detected upon the histopathological assessment of cholecystectomy biopsy. Adenocarcinoma is the most common phenotype of gallbladder cancer, which can be mild to moderately differentiated. Other malignant phenotypes include mucinous adenocarcinoma, signet cell, small cell, papillary adenocarcinoma, intestinal type adenocarcinoma, and undifferentiated carcinoma. The rarity of the disease makes the diagnosis extremely difficult in the initial phases. Liver abscesses are extremely rare and scarcely reported presentation of gallbladder cancer, with only a handful reported cases. It is speculated that the development of hepatic abscesses depicts direct involvement of hepatic parenchyma, development of associated necrosis, and superimposed bacterial infection evolving to an abscess. Gallbladder perforations are rare and potentially life-threatening complications of any gallbladder disease. Increased intraluminal pressure leads to mural necrosis, emphysematous changes in the wall, and vascular compromise which leads to gallbladder wall necrosis leading to perforation. Gallbladder tumors are exceedingly notorious for poor outcomes with very limited survival. Here, we present a case of a 69-year-old male who initially presented with impending perforation of the gallbladder with multiple hepatic masses, which were thought to be metastatic deposits. However, on biopsy, he was found to have multiple hepatic abscesses due to localized necrosis. Further workup revealed that the patient had an advanced metastatic gallbladder tumor that had passed the stage of tumor resection. Gallbladder perforations are classified according to Niemeier's classification. Our patient had a type II perforation which resulted in a hepatic abscess.

摘要

胆囊肿瘤是胆道最常见的肿瘤。它们虽罕见但具有临床侵袭性,可表现为转移性疾病,或偶尔在胆囊切除术活检的组织病理学评估中被发现。腺癌是胆囊癌最常见的表型,可呈轻度至中度分化。其他恶性表型包括黏液腺癌、印戒细胞癌、小细胞癌、乳头状腺癌、肠型腺癌和未分化癌。该疾病的罕见性使得在初始阶段诊断极为困难。肝脓肿是胆囊癌极为罕见且鲜有报道的表现,仅有少数病例报告。据推测,肝脓肿的发生表明肝实质直接受累、出现相关坏死,并叠加细菌感染演变为脓肿。胆囊穿孔是任何胆囊疾病罕见且可能危及生命的并发症。腔内压力增加导致壁层坏死、胆囊壁气肿性改变以及血管受损,进而导致胆囊壁坏死并穿孔。胆囊肿瘤因预后极差、生存期非常有限而声名狼藉。在此,我们报告一例69岁男性患者,其最初表现为胆囊即将穿孔并伴有多个肝脏肿块,这些肿块被认为是转移灶。然而,活检发现他因局部坏死而患有多个肝脓肿。进一步检查显示该患者患有晚期转移性胆囊肿瘤,已过肿瘤切除阶段。胆囊穿孔根据尼迈尔分类法进行分类。我们的患者为II型穿孔,导致了肝脓肿。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd8/10540506/11641b06b1dd/cureus-0015-00000044369-i01.jpg

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