Winokur G, Scharfetter C, Angst J
Eur Arch Psychiatry Neurol Sci. 1985;234(5):295-8. doi: 10.1007/BF00381039.
An evaluation was made of schizophrenics (140), schizoaffectives (40), unipolar depressives (59), and bipolars (30), and their relatives who had a chart diagnosis of psychosis or depressive neurosis. The purpose was to determine whether the psychosis (delusions and hallucinations) was transmitted independently of the illness itself. If this were true, there would be an excess of pairs of probands and relatives both positive for psychosis and pairs of relatives and probands both negative for psychosis when compared to relatives and probands who were not concordant for the variable. This was found to be true in schizophrenia and schizoaffective disorder and is probably the result of the simple transmission of an illness which includes the presence of psychotic symptoms in the definition. Thus, this would be a manifestation of the genetic propensity in schizophrenia. For the affective disorders there was no evidence that psychotic probands were more likely than the nonpsychotic to have psychotic relatives. So far the reason why some patients have psychosis and others not in the affective disorders remains unexplained.
对精神分裂症患者（140例）、分裂情感性障碍患者（40例）、单相抑郁症患者（59例）和双相情感障碍患者（30例）及其有图表诊断为精神病或抑郁性神经症的亲属进行了评估。目的是确定精神病（妄想和幻觉）是否独立于疾病本身进行传递。如果是这样，与在该变量上不一致的亲属和先证者相比，会有过多的先证者和亲属对精神病均呈阳性，以及亲属和先证者对精神病均呈阴性的情况。这在精神分裂症和分裂情感性障碍中被发现是正确的，这可能是一种疾病简单传递的结果，该疾病的定义中包括精神病症状的存在。因此，这将是精神分裂症遗传倾向的一种表现。对于情感障碍，没有证据表明有精神病的先证者比没有精神病的先证者更有可能有患精神病的亲属。到目前为止，情感障碍中一些患者有精神病而另一些患者没有的原因仍无法解释。
