Hovi T, Heikinheimo M
Eur J Clin Pharmacol. 1985;28(2):231-3. doi: 10.1007/BF00609699.
The steady state absorption of erythromycin from enteric-coated pellets of erythromycin base was compared with that from enteric-coated tablets in a randomized, two-way cross-over study in 24 healthy adult volunteers. A higher mean individual peak concentration (p less than 0.01), and a greater mean area under the serum concentration-time (0-8 h) curve (AUC, p less than 0.01) was produced by the enteric-coated pellets, when the preparations were administered 1 hour before breakfast. No significant differences in the kinetic parameters between the two preparations were observed when they were taken during a non-standardized breakfast, as concomitant food intake was found to reduce both the peak levels and the AUC-values (p less than 0.01) produced by the pelleted preparation.
在一项针对24名健康成年志愿者的随机、双向交叉研究中，对红霉素肠溶微丸和红霉素肠溶片的稳态吸收情况进行了比较。当在早餐前1小时服用制剂时，红霉素肠溶微丸产生了更高的平均个体峰浓度（p<0.01）以及更大的血清浓度-时间（0至8小时）曲线下平均面积（AUC，p<0.01）。当在非标准化早餐期间服用这两种制剂时，未观察到它们在动力学参数上存在显著差异，因为发现食物摄入会降低微丸制剂产生的峰浓度水平和AUC值（p<0.01）。
