硫酸苄胍对豚鼠乳头肌的电生理效应。

Electrophysiological effects of bethanidine sulfate on guinea-pig papillary muscle.

作者信息

Inoue D, Nakanishi T, Asayama J, Katsume H, Ijichi H

出版信息

Eur J Pharmacol. 1985 Feb 5;108(3):301-3. doi: 10.1016/0014-2999(85)90453-4.

Abstract

Bethanidine, a chemical analog of bretylium, increased the plateau phase of the action potential of guinea-pig papillary muscle in 2.7 mM K+ Tyrode solution without changing other electrophysiological parameters. In 25 mM K+ Tyrode solution, the amplitude, duration and Vmax of the Ca2+-dependent action potential were increased in a dose-dependent manner by bethanidine. It is speculated that the mechanism of antiarrhythmic effect of bethanidine might be due to the prolongation of action potential by an increase of the slow inward current.

摘要

苄乙胍是溴苄铵的化学类似物，在含2.7 mM钾离子的台氏液中，它可增加豚鼠乳头肌动作电位的平台期，而不改变其他电生理参数。在含25 mM钾离子的台氏液中，苄乙胍可使钙依赖性动作电位的幅度、时程和最大上升速率呈剂量依赖性增加。推测苄乙胍抗心律失常作用的机制可能是通过增加缓慢内向电流来延长动作电位。