Sawada Yuta, Tamai Koji, Toyoda Hiromitsu, Kato Minori, Suzuki Akinobu, Takahashi Shinji, Iwamae Masayoshi, Okamura Yuki, Kobayashi Yuto, Nakamura Hiroaki, Terai Hidetomi
Department of Orthopedics, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Global Spine J. 2025 Jan 29:21925682251318266. doi: 10.1177/21925682251318266.
Retrospective cohort study.
Spinal surgeons face a dilemma regarding the continuation or discontinuation of antiplatelet agents during the perioperative period. Guidelines recommend considering the balance between thrombotic and bleeding risks. However, no consensus exists for the use of these agents for patients who undergo minimally invasive lumbar decompression. This study aimed to assess the effect of continued antiplatelet medication on minimally invasive posterior lumbar decompression surgery outcomes, focusing on perioperative outcomes and 1-year postoperative clinical results.
This study included 106 patients who underwent minimally invasive posterior lumbar decompression between 2017 and 2022 and were taking antiplatelet medications before spinal surgery. Patient characteristics, antiplatelet medication type, and perioperative data were analyzed. Patients were divided into "continuation" and "discontinuation" groups based on preoperative antiplatelet medication status. Univariate and multivariate linear regression analyses were performed.
No significant differences were observed between groups in terms of surgical time, intraoperative blood loss, postoperative drain volume, complication rates, and Japanese Orthopedic Association scores and EuroQoL-5 dimensions 5-level at 1 year postoperatively. Similar results were noted in groups focusing exclusively on patients treated with aspirin. Multivariate linear regression revealed that surgical time per level was significantly associated with total blood loss, whereas antiplatelet medications did not show a significant relationship (operative time per level, < 0.01; antiplatelet drugs, = 0.459).
This study suggests that minimally invasive posterior lumbar spine decompression can be performed safely and effectively under continuous antiplatelet medication. Further studies with more evidence are required to validate our findings.
回顾性队列研究。
脊柱外科医生在围手术期面临抗血小板药物继续使用或停用的两难困境。指南建议考虑血栓形成和出血风险之间的平衡。然而,对于接受微创腰椎减压的患者使用这些药物尚无共识。本研究旨在评估继续使用抗血小板药物对微创后路腰椎减压手术结果的影响,重点关注围手术期结果和术后1年的临床结果。
本研究纳入了2017年至2022年间接受微创后路腰椎减压且在脊柱手术前正在服用抗血小板药物的106例患者。分析患者特征、抗血小板药物类型和围手术期数据。根据术前抗血小板药物使用情况将患者分为“继续使用”组和“停用”组。进行单因素和多因素线性回归分析。
两组在手术时间、术中出血量、术后引流量、并发症发生率、日本骨科协会评分以及术后1年的欧洲五维健康量表5级评分方面均未观察到显著差异。仅关注阿司匹林治疗患者的组也得到了类似结果。多因素线性回归显示,每节段手术时间与总失血量显著相关,而抗血小板药物未显示出显著相关性(每节段手术时间,<0.01;抗血小板药物,=0.459)。
本研究表明,在持续使用抗血小板药物的情况下,微创后路腰椎减压手术可以安全有效地进行。需要更多证据的进一步研究来验证我们的发现。