Felesina Thomas, Zietsch Brendan P
Centre for Psychology and Evolution, School of Psychology, University of Queensland, Queensland, Australia.
Centre for Psychology and Evolution, School of Psychology, University of Queensland, Queensland, Australia.
Trends Genet. 2025 May;41(5):402-411. doi: 10.1016/j.tig.2024.12.005. Epub 2025 Jan 28.
Thanks to twin studies, it has been known for decades that human same-sex sexual behavior (SSB) has a substantial heritable component. However, only recently have large genome-wide association studies (GWAS) begun to illuminate the complex genetics involved. These studies have established that SSB is influenced by many common genetic variants, each with tiny but cumulative effects. The evolutionary explanation for the persistence of genetic variants associated with SSB, despite their apparent fitness costs, remains uncertain. In this review, we synthesize advances in understanding the genetic and evolutionary bases of SSB, while identifying the many areas in which we still have much to learn.
多亏了双胞胎研究，几十年来我们已经知道人类的同性性行为（SSB）有很大一部分是可遗传的。然而，直到最近，大规模的全基因组关联研究（GWAS）才开始揭示其中涉及的复杂遗传学。这些研究已经证实，同性性行为受到许多常见基因变异的影响，每个变异的影响虽小，但会累积起来。尽管与同性性行为相关的基因变异明显存在适应性成本，但它们持续存在的进化解释仍然不确定。在这篇综述中，我们综合了在理解同性性行为的遗传和进化基础方面取得的进展，同时指出了许多我们仍有很多要学习的领域。
