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Pembrolizumab added to neoadjuvant chemotherapy may improve pathological complete response in androgen-receptor positive and low tumor-infiltrating lymphocytes triple-negative breast cancer patients.

作者信息

Altundag Kadri

机构信息

Tepe Prime, MKA Breast Cancer Clinic, 06800, Ankara, Turkey.

出版信息

Breast Cancer. 2025 Mar;32(2):456. doi: 10.1007/s12282-025-01672-z. Epub 2025 Jan 29.

DOI:10.1007/s12282-025-01672-z
PMID:39881092
Abstract
摘要

相似文献

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2
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A phase II, randomized, open-labeled study to evaluate low-dose pembrolizumab in addition to neoadjuvant chemotherapy for triple-negative breast cancer (TNBC).一项II期随机开放标签研究,旨在评估低剂量帕博利珠单抗联合新辅助化疗用于三阴性乳腺癌(TNBC)的疗效。
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Pembrolizumab plus chemotherapy as neoadjuvant treatment of high-risk, early-stage triple-negative breast cancer: results from the phase 1b open-label, multicohort KEYNOTE-173 study.帕博利珠单抗联合化疗作为高危早期三阴性乳腺癌的新辅助治疗:来自 1b 期开放标签、多队列 KEYNOTE-173 研究的结果。
Ann Oncol. 2020 May;31(5):569-581. doi: 10.1016/j.annonc.2020.01.072. Epub 2020 Feb 14.

本文引用的文献

1
Clinicopathological significance of androgen receptor expression and tumor infiltrating lymphocytes in triple-negative breast cancer: a retrospective cohort study.雄激素受体表达及肿瘤浸润淋巴细胞在三阴性乳腺癌中的临床病理意义:一项回顾性队列研究
Breast Cancer. 2025 Mar;32(2):357-368. doi: 10.1007/s12282-024-01662-7. Epub 2024 Dec 27.
2
Overall Survival with Pembrolizumab in Early-Stage Triple-Negative Breast Cancer.帕博利珠单抗治疗早期三阴性乳腺癌的总生存期。
N Engl J Med. 2024 Nov 28;391(21):1981-1991. doi: 10.1056/NEJMoa2409932. Epub 2024 Sep 15.