Chen Nuo, Liu Xiaolan, Wang Lulu, Yu Hui, Liu Fangqian, Yuan Mengran, Wang Qimeng, Zhang Tianyi, Zhou Xiaoxiang, Wang Hua, Ji Zengjun, Shen Hongxing
Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, P. R. China.
Cardiothoracic surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, P. R. China.
Future Microbiol. 2025 Mar;20(4):345-355. doi: 10.1080/17460913.2025.2459530. Epub 2025 Jan 29.
Prohibitins (PHBs) are members of a highly conserved family of proteins, including prohibitin1 and prohibitin2. These proteins are predominantly localized in mitochondria, the nucleus, and cell membranes, where they play critical roles in mitochondrial biogenesis, apoptosis, immune regulation, and other biological processes. Recent studies have demonstrated that both PHB1 and PHB2 can act as a complex or independently to participate in the pathogen infection process. This review focuses on the regulatory roles of PHB1 and PHB2 in viral, bacterial, parasitic and fungal infections, providing a theoretical basis and innovative perspectives for a comprehensive understanding of the roles and mechanisms of PHB1 and PHB2 in the regulation of microbial infections. Due to exerting multiple functions, PHB proteins have been recognized as a potential target for therapeutic interventions, with the expectation that targeting PHB proteins will provide new strategies for the treatment of infection-related diseases.
prohibitin（PHB）蛋白是一个高度保守的蛋白质家族成员，包括 prohibitin1 和 prohibitin2。这些蛋白质主要定位于线粒体、细胞核和细胞膜，在那里它们在线粒体生物发生、细胞凋亡、免疫调节和其他生物学过程中发挥关键作用。最近的研究表明，PHB1 和 PHB2 都可以作为一个复合体或独立发挥作用，参与病原体感染过程。本综述重点关注 PHB1 和 PHB2 在病毒、细菌、寄生虫和真菌感染中的调节作用，为全面了解 PHB1 和 PHB2 在微生物感染调节中的作用和机制提供理论基础和创新观点。由于 PHB 蛋白发挥多种功能，它们已被认为是治疗干预的潜在靶点，期望靶向 PHB 蛋白将为感染相关疾病的治疗提供新策略。
