Qiu Dachang, Wang Lin, Wang Lanlan, Dong Yongfei
Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Department of Geriatrics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Front Neurosci. 2025 Jan 15;18:1517601. doi: 10.3389/fnins.2024.1517601. eCollection 2024.
Intracerebral hemorrhage (ICH) is a major public health challenge worldwide, and is associated with elevated rates of mortality, disability, and morbidity, especially in low- and middle-income nations. However, our knowledge of the detailed molecular processes involved in ICH remains insufficient, particularly those involved in the secondary injury stage, resulting in a lack of effective treatments for ICH. Human platelet lysates (HPL) are abundant in bioactive factors, and numerous studies have demonstrated their beneficial effects on neurological diseases, including their anti-neuroinflammatory ability, anti-oxidant effects, maintenance of blood-brain barrier integrity, and promotion of neurogenesis. In this review, we thoroughly explore the potential of HPL for treating ICH from three critical perspectives: the rationale for selecting HPL as a treatment for ICH, the mechanisms through which HPL contributes to ICH management, and the additional measures necessary for HPL as a treatment for ICH. We elucidate the role of platelets in ICH pathophysiology and highlight the limitations of the current treatment options and advancements in preclinical research on the application of HPL in neurological disorders. Furthermore, historical developments and preparation methods of HPL in the field of biomedicine are discussed. Additionally, we summarize the bioactive molecules present in HPL and their potential therapeutic effects in ICH. Finally, we outline the issues that must be addressed regarding utilizing HPL as a treatment modality for ICH.
脑出血（ICH）是全球主要的公共卫生挑战，与死亡率、残疾率和发病率的升高相关，尤其是在低收入和中等收入国家。然而，我们对脑出血所涉及的详细分子过程的了解仍然不足，特别是那些在继发性损伤阶段所涉及的过程，这导致缺乏针对脑出血的有效治疗方法。人血小板裂解物（HPL）富含生物活性因子，众多研究已证明其对神经系统疾病具有有益作用，包括其抗神经炎症能力、抗氧化作用、维持血脑屏障完整性以及促进神经发生。在本综述中，我们从三个关键角度深入探讨了HPL治疗脑出血的潜力：选择HPL作为脑出血治疗方法的基本原理、HPL有助于脑出血治疗的机制，以及将HPL用作脑出血治疗方法所需的额外措施。我们阐明了血小板在脑出血病理生理学中的作用，并强调了当前治疗选择的局限性以及HPL在神经系统疾病应用方面临床前研究的进展。此外，还讨论了生物医学领域中HPL的历史发展和制备方法。此外，我们总结了HPL中存在的生物活性分子及其在脑出血中的潜在治疗作用。最后，我们概述了将HPL用作脑出血治疗方式时必须解决的问题。
