Mehri Marjan, Golitaleb Mohamad, Safdari Ali, Madadi Sabah, Rafiei Fatemeh, Shahbazi Hossein, Mokhtari Razieh, Nejat Nazi
Department of Internal Medicine, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Department of Critical Care Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.
Contemp Clin Trials Commun. 2025 Jan 6;44:101427. doi: 10.1016/j.conctc.2025.101427. eCollection 2025 Apr.
Patients with leukemia undergoing bone marrow aspiration (BMA) frequently experience considerable pain and anxiety, which may negatively impact physiological outcomes. Reflexology, a complementary therapeutic approach, has demonstrated effectiveness in reducing pain and anxiety across various medical procedures. This randomized clinical trial aimed to evaluate the impact of foot reflexology on pain, anxiety, and physiological indices in leukemia patients undergoing BMA.
This randomized clinical trial was conducted at Ayatollah Khansari Hospital in Arak between August 2021 and January 2023. Patients were randomly assigned to either a reflexology intervention group or a control group receiving routine care. The intervention group underwent a 30-min foot reflexology session. Pain was assessed using the Numeric Rating Scale (NRS), and anxiety levels were measured via the Spielberger State-Trait Anxiety Inventory (STAI). Physiological indices, including systolic and diastolic blood pressure, heart rate, and arterial oxygen saturation, were measured before and after the intervention.
Of the 72 patients, 68 completed the study (intervention: n = 35, control: n = 33). Post-intervention, the intervention group showed a significant reduction in systolic (p = 0.017) and diastolic blood pressure (p = 0.028), while the control group experienced no significant changes. Heart rate significantly increased in the control group (p = 0.030), but no significant change was observed in the intervention group (p = 0.977). Anxiety levels significantly decreased in the intervention group (p < 0.001), with a notable between-group difference (p = 0.006). Pain intensity was also significantly lower in the intervention group compared to the control group (p = 0.034).
Foot reflexology is an effective intervention for reducing pain and anxiety in leukemia patients undergoing BMA. Reflexology may be considered a valuable, non-invasive supportive therapy for managing procedural pain and anxiety in oncology settings.
接受骨髓穿刺（BMA）的白血病患者经常会经历相当大的疼痛和焦虑，这可能会对生理结果产生负面影响。反射疗法作为一种辅助治疗方法，已证明在各种医疗程序中能有效减轻疼痛和焦虑。这项随机临床试验旨在评估足部反射疗法对接受BMA的白血病患者的疼痛、焦虑和生理指标的影响。
这项随机临床试验于2021年8月至2023年1月在阿拉克的阿亚图拉·汗萨里医院进行。患者被随机分为反射疗法干预组或接受常规护理的对照组。干预组接受了30分钟的足部反射疗法。使用数字评分量表（NRS）评估疼痛，并通过斯皮尔伯格状态-特质焦虑量表（STAI）测量焦虑水平。在干预前后测量生理指标，包括收缩压和舒张压、心率和动脉血氧饱和度。
72名患者中，68名完成了研究（干预组：n = 35，对照组：n = 33）。干预后，干预组的收缩压（p = 0.017）和舒张压（p = 0.028）显著降低，而对照组无显著变化。对照组的心率显著增加（p = 0.030），而干预组未观察到显著变化（p = 0.977）。干预组的焦虑水平显著降低（p < 0.001），组间差异显著（p = 0.006）。与对照组相比，干预组的疼痛强度也显著降低（p = 0.034）。
足部反射疗法是减轻接受BMA的白血病患者疼痛和焦虑的有效干预措施。反射疗法可被视为在肿瘤学环境中管理程序性疼痛和焦虑的一种有价值的非侵入性支持疗法。
