Cobb Ryon J, Thorpe Roland J, Norris Keith N
School of Social Work, Rutgers University, New Brunswick, New Jersey, USA.
Department of Health, Behavior, and Society, Johns Hopkins Bloomsburg School of Public Health, Baltimore, Maryland, USA.
Innov Aging. 2024 Jun 28;9(1):igae064. doi: 10.1093/geroni/igae064. eCollection 2025.
Older patients diagnosed with chronic kidney disease (CKD) have a higher risk of all-cause mortality than the general population. However, there is limited information available on how CKD relates to all-cause mortality among Black adults in the United States. We aimed to investigate how CKD relates to all-cause mortality risk among older Black adults.
This study draws on a subsample of self-identified Black participants ( = 1 393) from the Health and Retirement Study ages 52 to 96 who completed the anthropomorphic and biomarker supplement in 2006/2008. Our measure of CKD derives from serum cystatin C-based using dried blood spots, and all-cause mortality derives from the National Death Index and a key informant within the household from 2006 to 2019.
Twenty-nine percent of respondents died during the study period, whereas 31% had CKD. The mean age of the entire sample is 64.52. Results from our Cox proportional hazards models showed that CKD was independently associated with an increased risk of death from all causes among older Black participants in a model that adjusted for demographics, behavioral, clinical, and health characteristics.
Results from our study confirm that CKD is associated with increased risk of death from all causes among older Black adults. Future studies should examine whether changes in CKD over time relate to all-cause mortality risk among older Black adults.
被诊断患有慢性肾脏病(CKD)的老年患者全因死亡率高于普通人群。然而,关于美国黑人成年人中CKD与全因死亡率之间的关系,现有信息有限。我们旨在研究CKD与老年黑人成年人全因死亡风险之间的关系。
本研究采用了健康与退休研究中52至96岁自我认定为黑人的参与者(n = 1393)的子样本,这些参与者在2006/2008年完成了人体测量和生物标志物补充调查。我们对CKD的测量基于使用干血斑的血清胱抑素C,全因死亡率来自国家死亡指数以及2006年至2019年家庭中的关键信息提供者。
在研究期间,29%的受访者死亡,而31%的人患有CKD。整个样本的平均年龄为64.52岁。我们的Cox比例风险模型结果显示,在调整了人口统计学、行为、临床和健康特征的模型中,CKD与老年黑人参与者全因死亡风险增加独立相关。
我们的研究结果证实,CKD与老年黑人成年人全因死亡风险增加有关。未来的研究应探讨CKD随时间的变化是否与老年黑人成年人的全因死亡风险相关。