无糖尿病老年人中体重调整腰围指数与认知功能的关联：一项横断面研究。
Association Between Weight-Adjusted Waist Index and Cognitive Function in Older Adults Without Diabetes: A Cross-Sectional Study.
作者信息
Wang Qing, Yin Yishan, Liu Wei, Li Lingyu, Wang Zhen, Tian Yue, Fan Jing
机构信息
Department of Laboratory Medicine, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, 253000, People's Republic of China.
Department of Orthopedics, The Armed Police Forces Hospital of Shandong, Jinan, Shandong, 250000, People's Republic of China.
出版信息
Clin Interv Aging. 2025 Jan 25;20:69-79. doi: 10.2147/CIA.S499221. eCollection 2025.
BACKGROUND
This study investigates the correlation between the weight-adjusted waist index (WWI) and cognitive performance in the senior American population, focusing on those without diabetes from 2011 to 2014.
METHODS
We analyzed data from the 2011-2012 and 2013-2014 National Health and Nutrition Examination Surveys (NHANES), focusing on non-diabetic participants aged 60 and older who completed cognitive tests: Establish a Registry for Alzheimer's disease (CERAD), the Animal Fluency test (AFT), and Digit Symbol Substitution test (DSST). WWI was calculated using waist circumference divided by the square root of body weight. We employed linear univariate and multivariate analyses, along with curve fitting, we conducted subgroup and interaction analyses to elucidate the relationships under investigation.
RESULTS
The study incorporated a cohort of 1649 participants aged 60 years and older, each with a complete set of data, enabling a thorough analysis. After adjusting for confounding factors, significant negative correlations were found between WWI and both CERAD (β: -0.48; 95% CI: -0.92 to -0.05; P=0.03) and DSST (β: -1.15; 95% CI: -2.09 to -0.21; P=0.017) scores, suggesting a link to cognitive decline. No association was found with AFT scores. The relationship between WWI and DSST was found to be nonlinear (P for non-linearity=0.022). Additionally, the association between WWI and CERAD was also observed (P for non-linearity=0.042). However, linear relationships were observed between WWI and AFT (P for non-linearity=0.418). The subgroup analysis was overall stable.
CONCLUSION
Our cross-sectional study indicates a strong link between a high WWI and reduced cognitive function in non-diabetic older Americans, as shown by CERAD and DSST scores. Attaining an optimal WWI may be vital for cognitive decline, highlighting its role in a potential preventative approach.
CLINICAL TRIAL REGISTRY NUMBER AND WEBSITE WHERE IT WAS OBTAINED
The study design and data are publicly accessible at www.cdc.gov/nchs/nhanes/.
背景
本研究调查了美国老年人群中体重调整腰围指数（WWI）与认知表现之间的相关性，重点关注2011年至2014年无糖尿病的人群。
方法
我们分析了2011 - 2012年和2013 - 2014年国家健康与营养检查调查（NHANES）的数据，重点关注60岁及以上完成认知测试的非糖尿病参与者：阿尔茨海默病注册登记（CERAD）、动物流畅性测试（AFT）和数字符号替换测试（DSST）。WWI通过腰围除以体重平方根来计算。我们采用线性单变量和多变量分析以及曲线拟合，进行亚组和交互分析以阐明所研究的关系。
结果
该研究纳入了1649名60岁及以上的参与者队列，每人都有完整的数据集，从而能够进行全面分析。在调整混杂因素后，发现WWI与CERAD（β： - 0.48；95% CI： - 0.92至 - 0.05；P = 0.03）和DSST（β： - 1.15；95% CI： - 2.09至 - 0.21；P = 0.017）得分之间存在显著负相关，表明与认知能力下降有关。未发现与AFT得分有相关性。发现WWI与DSST之间的关系是非线性的（非线性P = 0.022）。此外，也观察到了WWI与CERAD之间的关联（非线性P = 0.042）。然而，观察到WWI与AFT之间存在线性关系（非线性P = 0.418）。亚组分析总体稳定。
结论
我们的横断面研究表明，如CERAD和DSST得分所示，高WWI与非糖尿病美国老年人认知功能下降之间存在密切联系。达到最佳WWI对于认知能力下降可能至关重要，突出了其在潜在预防方法中的作用。
临床试验注册号及获取网站
该研究设计和数据可在www.cdc.gov/nchs/nhanes/上公开获取。
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