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病例报告：青少年肋骨软骨肉瘤样恶性巨细胞瘤1例：诊断挑战与治疗

Case report: A rare case of chondrosarcoma-like malignant giant cell tumor in adolescent rib: diagnostic challenges and treatment.

作者信息

Qin Zhuolin, Li Longqian, Jing Tao, Wang Cheng

机构信息

The Second Clinical Medical College, Lanzhou University, Lanzhou, China.

Department of Thoracic Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China.

出版信息

Front Oncol. 2025 Jan 15;14:1523104. doi: 10.3389/fonc.2024.1523104. eCollection 2024.

DOI:10.3389/fonc.2024.1523104
PMID:39882444
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11774699/
Abstract

Chondrosarcoma-like malignant giant cell tumor (GCT) of the rib is an extremely rare and aggressive tumor, particularly in adolescents. This case report describes a 19-year-old female presenting with a GCT of the rib with chondrosarcomatous differentiation, highlighting the challenges posed by its unusual location and pathological complexity. Multidisciplinary diagnostic approaches, including advanced imaging, immunohistochemistry (IHC), and pathology, were essential for confirming the diagnosis. Key IHC markers such as Vimentin, SMA, and CD163, alongside genetic analysis excluding H3F3A mutations, guided the diagnostic process. The patient underwent successful surgical resection, achieving early recovery without adjuvant therapy. This report underscores the importance of early detection, precise pathological evaluation, and individualized surgical treatment for rare and high-risk tumors, emphasizing the need for long-term follow-up to monitor recurrence.

摘要

肋骨软骨肉瘤样恶性巨细胞瘤（GCT）极为罕见且具有侵袭性，在青少年中尤为如此。本病例报告描述了一名19岁女性，患有具有软骨肉瘤分化的肋骨GCT，凸显了其不寻常的位置和病理复杂性所带来的挑战。多学科诊断方法，包括先进的影像学检查、免疫组织化学（IHC）和病理学检查，对于确诊至关重要。关键的IHC标志物如波形蛋白、平滑肌肌动蛋白和CD163，以及排除H3F3A突变的基因分析，指导了诊断过程。患者接受了成功的手术切除，无需辅助治疗即可早期康复。本报告强调了早期发现、精确的病理评估和针对罕见高危肿瘤的个体化手术治疗的重要性，强调了长期随访以监测复发的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62d8/11774699/83cc45ff98c0/fonc-14-1523104-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62d8/11774699/0e1dc301b4b8/fonc-14-1523104-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62d8/11774699/66914a2e67c0/fonc-14-1523104-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62d8/11774699/9c29ee4b5a25/fonc-14-1523104-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62d8/11774699/83cc45ff98c0/fonc-14-1523104-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62d8/11774699/0e1dc301b4b8/fonc-14-1523104-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62d8/11774699/66914a2e67c0/fonc-14-1523104-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62d8/11774699/9c29ee4b5a25/fonc-14-1523104-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62d8/11774699/83cc45ff98c0/fonc-14-1523104-g004.jpg

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