40 is the new 50: reducing the need for platelet transfusions prior to lumbar puncture in adults with hematologic malignancies.
作者信息
Corrao Kristen, Umpierrez Adrian, Treml Angela, Szabo Aniko, Michaelis Laura, Runaas Lyndsey, Murthy Guru Subramanian Guru, Abedin Sameem, Carlson Karen, Kreuziger Lisa Baumann, Atallah Ehab
机构信息
Medical College of Wisconsin, Milwaukee, WI.
Emory University, Atlanta, GA.
出版信息
Haematologica. 2025 Aug 1;110(8):1845-1848. doi: 10.3324/haematol.2023.284321. Epub 2025 Jan 30.
Abstract
摘要
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40 is the new 50: reducing the need for platelet transfusions prior to lumbar puncture in adults with hematologic malignancies.40岁如今等同于50岁：减少血液系统恶性肿瘤成年患者腰椎穿刺术前血小板输注的需求。
Haematologica. 2025 Aug 1;110(8):1845-1848. doi: 10.3324/haematol.2023.284321. Epub 2025 Jan 30.
2
Use of platelet transfusions prior to lumbar punctures or epidural anaesthesia for the prevention of complications in people with thrombocytopenia.在腰椎穿刺或硬膜外麻醉前使用血小板输注以预防血小板减少症患者的并发症。
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Use of platelet transfusions prior to lumbar punctures or epidural anaesthesia for the prevention of complications in people with thrombocytopenia.在腰椎穿刺或硬膜外麻醉前使用血小板输注以预防血小板减少症患者的并发症。
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4
Plasma transfusions prior to lumbar punctures and epidural catheters for people with abnormal coagulation.对于凝血功能异常的患者，在进行腰椎穿刺和硬膜外导管置入之前进行血浆输注。
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Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after chemotherapy and stem cell transplantation.预防性血小板输注用于预防血液系统疾病患者化疗和干细胞移植后的出血。
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Prophylactic platelet transfusions prior to surgery for people with a low platelet count.血小板计数低的患者在手术前进行预防性血小板输注。
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Pathogen-reduced platelets for the prevention of bleeding.用于预防出血的去病原体血小板。
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A therapeutic-only versus prophylactic platelet transfusion strategy for preventing bleeding in patients with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation.一种仅用于治疗与预防性血小板输注策略，用于预防血液系统疾病患者在骨髓抑制性化疗或干细胞移植后出血。
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Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation.比较不同血小板计数阈值，以指导预防性血小板输注的应用，从而预防血液系统疾病患者在骨髓抑制性化疗或干细胞移植后发生出血。
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Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support.对于接受强化化疗或放疗或两者联合治疗、有或没有造血干细胞支持的血液系统恶性肿瘤患者，采用限制性与宽松性红细胞输血策略的比较。
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引用本文的文献
1
Safe platelet count for lumbar puncture: are we being overcautious?腰椎穿刺的安全血小板计数：我们是否过于谨慎了？
Haematologica. 2025 Aug 1;110(8):1667-1669. doi: 10.3324/haematol.2025.287359. Epub 2025 Mar 13.
本文引用的文献
1
Can we lower the platelet threshold of ≥ 50 × 10/L for performing a lumbar puncture safely in patients with hematological malignancies?我们能否将血小板阈值降低至≥50×10/L，以安全地对患有血液系统恶性肿瘤的患者进行腰椎穿刺？
Ann Hematol. 2023 Mar;102(3):663-668. doi: 10.1007/s00277-022-05073-6. Epub 2022 Dec 19.
2
Rethinking the need for a platelet transfusion threshold of 50 × 10 /L for lumbar puncture in cancer patients.重新思考癌症患者腰椎穿刺时血小板输注阈值为50×10⁹/L的必要性。
Transfusion. 2020 Oct;60(10):2243-2249. doi: 10.1111/trf.15988. Epub 2020 Aug 18.
3
Guidelines for the use of platelet transfusions.血小板输注的使用指南。
Br J Haematol. 2017 Feb;176(3):365-394. doi: 10.1111/bjh.14423. Epub 2016 Dec 23.
4
Subdural Hematoma Associated with Dasatinib and Intrathecal Methotrexate Treatment in Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia.费城染色体阳性急性淋巴细胞白血病中与达沙替尼和鞘内注射甲氨蝶呤治疗相关的硬膜下血肿
Intern Med. 2016;55(18):2703-6. doi: 10.2169/internalmedicine.55.6966. Epub 2016 Sep 15.
5
Safety of lumbar punctures in patients with thrombocytopenia.血小板减少症患者腰椎穿刺的安全性。
Vox Sang. 2016 May;110(4):393-400. doi: 10.1111/vox.12381. Epub 2016 Feb 2.
6
The BCR-ABL inhibitor ponatinib inhibits platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling, platelet activation and aggregate formation under shear.BCR-ABL抑制剂波纳替尼可抑制血小板免疫受体酪氨酸激活基序（ITAM）信号传导、血小板激活以及在剪切力作用下的聚集形成。
Thromb Res. 2015 Jan;135(1):155-60. doi: 10.1016/j.thromres.2014.11.009. Epub 2014 Nov 18.
7
Platelet transfusion: a clinical practice guideline from the AABB.血小板输注：AABB 临床实践指南。
Ann Intern Med. 2015 Feb 3;162(3):205-13. doi: 10.7326/M14-1589.
8
Safety of platelet transfusion: past, present and future.血小板输注的安全性：过去、现在与未来。
Vox Sang. 2014 Aug;107(2):103-13. doi: 10.1111/vox.12146. Epub 2014 Mar 20.
9
The risk of spinal haematoma following neuraxial anaesthesia or lumbar puncture in thrombocytopenic individuals.血小板减少症患者行椎管内麻醉或腰椎穿刺后发生脊髓血肿的风险。
Br J Haematol. 2010 Jan;148(1):15-25. doi: 10.1111/j.1365-2141.2009.07899.x. Epub 2009 Sep 22.
10
Tyrosine kinase inhibitor-induced platelet dysfunction in patients with chronic myeloid leukemia.酪氨酸激酶抑制剂诱发慢性髓性白血病患者的血小板功能障碍。
Blood. 2009 Jul 9;114(2):261-3. doi: 10.1182/blood-2008-09-180604. Epub 2009 May 4.
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