Bayraktar İzgi, Yalçın Nadir, Nalbant Kevser, Kültür Ebru Çengel, Demirkan Kutay
Department of Clinical Pharmacy, Hacettepe University Faculty of Pharmacy, Türkiye.
Department of Child and Adolescent Psychiatry, Hacettepe University, Faculty of Medicine, Türkiye.
Clin Child Psychol Psychiatry. 2025 Apr;30(2):516-528. doi: 10.1177/13591045251316607. Epub 2025 Jan 30.
Adolescents with mental illnesses often struggle with adhering to prescribed medication regimens. This study investigates how patient perceptions influence medication adherence among adolescents with psychiatric disorders. It also examines the role of patient characteristics and medication-related factors on adherence and attitudes. The Pediatric Medication Adherence Scale (PMAS)- 9 questions and the Pediatric Attitude toward Medication Scale (PAMS)- 18 questions, two reliable self-report scales designed for the adolescent population, were used to assess negative adherence behaviors and patients' perceptions of medication. Statistical analysis examined correlations between adherence, attitudes, and patient characteristics. The scales were administered to 288 adolescents with psychiatric disorders, and a significant correlation was found between concern scores and attitudes toward medication (r = 0.886, < .05). Patients receiving monotherapy demonstrated lower concern scores and more positive attitudes ( < .05). Experiencing side effects was significantly linked to reduced medication adherence and more negative attitudes toward treatment. Patients with eating disorders demonstrated more negative attitudes, while those using antidepressant-antipsychotic combinations demonstrated more negative attitudes than those using stimulants. This study emphasizes the necessity of addressing critical factors that influence medication adherence and attitudes toward psychiatric medication among adolescents with psychiatric disorders. In particular, it highlights the importance of considering concern perception, managing side effects, and evaluating polypharmacy to optimize pharmacotherapy in this population.
患有精神疾病的青少年在坚持规定的药物治疗方案方面常常存在困难。本研究调查了患者认知如何影响患有精神障碍的青少年的药物依从性。它还考察了患者特征和药物相关因素在依从性及态度方面所起的作用。使用儿科药物依从性量表（PMAS）——9个问题，以及儿科药物态度量表（PAMS）——18个问题，这两个专为青少年人群设计的可靠的自我报告量表，来评估负面的依从行为和患者对药物的认知。统计分析考察了依从性、态度和患者特征之间的相关性。这些量表被施用于288名患有精神障碍的青少年，结果发现担忧得分与对药物的态度之间存在显著相关性（r = 0.886，P <.05）。接受单一疗法的患者担忧得分较低，态度更为积极（P <.05）。经历副作用与药物依从性降低及对治疗的态度更消极显著相关。患有饮食失调症的患者态度更为消极，而使用抗抑郁药与抗精神病药联合用药的患者比使用兴奋剂的患者态度更消极。本研究强调了解决影响患有精神障碍的青少年药物依从性和对精神科药物态度的关键因素的必要性。特别是，它突出了考虑担忧认知、管理副作用以及评估联合用药以优化该人群药物治疗的重要性。
