Smadar Lital, Kapelushnik Noa, Ben-Simon Guy J, Segev Shlomo, Soudry Shahar, Abd-Elkader Amir, Landau Prat Daphna
Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel.
Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
Semin Ophthalmol. 2025 Jul;40(5):400-404. doi: 10.1080/08820538.2025.2459311. Epub 2025 Jan 30.
Blepharitis and lower eyelid ectropion are highly prevalent ocular conditions occurring in 37%-46% and 2-3% of the general adult population, respectively. Blepharitis has multifactorial origins and involves anterior and posterior types of eyelid inflammation. Lower eyelid ectropion results in ocular surface exposure, epiphora and chronic conjunctivitis. This study aims to investigate any possible association between both conditions.
Medical records of 37,692 consecutive patients examined at a single medical screening center between 2001-2020 were retrospectively analyzed.
The prevalence of lower eyelid ectropion and of blepharitis, a possible association between the two, and the relation of each to age and sex.
A total of 35,670 patients were included. Ectropion was diagnosed in 69 patients (0.2%), and blepharitis in 4725 patients (13.2%). Male sex was more prevalent for each pathology (88.4% ectropion, and 85% blepharitis, < .001). Older age was associated with each diagnosis (77.3 years for ectropion patients vs. 52.2 years for the general screened population and 60.5 years for blepharitis patients vs 52.2 years for the general screened population < .001). The prevalence of ectropion was significantly higher in patients with coexisting blepharitis compared to those without (0.8% vs. 0.1%, respectively, < .001).
Ectropion was significantly more prevalent in patients with blepharitis. Both conditions were associated with older age and male sex. This coexistence can aid in decision making of early surgical intervention of lower eyelid ectropion as well as the approach to medical treatment of blepharitis.
睑缘炎和下睑外翻是常见的眼部疾病，在普通成年人群中的发生率分别为37%-46%和2%-3%。睑缘炎病因多因素，涉及睑缘前部和后部炎症。下睑外翻导致眼表暴露、溢泪和慢性结膜炎。本研究旨在调查这两种疾病之间是否存在任何可能的关联。
回顾性分析了2001年至2020年期间在单一医疗筛查中心接受检查的37692例连续患者的病历。
下睑外翻和睑缘炎的患病率、两者之间可能的关联以及各与年龄和性别的关系。
共纳入35670例患者。69例（0.2%）诊断为外翻，4725例（13.2%）诊断为睑缘炎。每种疾病男性更为常见（外翻患者中男性占88.4%，睑缘炎患者中男性占85%，P＜0.001）。年龄较大与每种诊断相关（外翻患者平均年龄77.3岁，而总体筛查人群为52.2岁；睑缘炎患者平均年龄60.5岁，而总体筛查人群为52.2岁，P＜0.001）。与无睑缘炎的患者相比，合并睑缘炎的患者中外翻患病率显著更高（分别为0.8%和0.1%，P＜0.001）。
睑缘炎患者中外翻的患病率显著更高。这两种疾病都与年龄较大和男性性别有关。这种共存情况有助于指导下睑外翻早期手术干预的决策以及睑缘炎的药物治疗方法。
