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脂质体两性霉素B与补体激活相关的假过敏反应（CARPA）。

Liposomal amphotericin B and complement activation-related pseudoallergy (CARPA).

作者信息

Thompson George R, Sani Gelina M, Donnelley Monica A, Figueroa Jaimie K, Ciuffetelli Ryan, Trigg Kate, Arredondo Juan, Koff Alan, Nearing Marie, Loque Ikaika C, Bays Derek J, Dandekar Satya

机构信息

Department of Internal Medicine, Division of Infectious Diseases, University of California-Davis Medical Center, Sacramento, California, USA.

Department of Medical Microbiology and Immunology, University of California-Davis, Davis, California, USA.

出版信息

Antimicrob Agents Chemother. 2025 Mar 5;69(3):e0169224. doi: 10.1128/aac.01692-24. Epub 2025 Jan 30.

DOI:10.1128/aac.01692-24
PMID:39882912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11881558/
Abstract

Infusion reactions (tachycardia, hypertension, fever, etc.) associated with liposomal amphotericin B are common. Animal models have found complement activation responsible, yet the pathophysiology has not been evaluated in human patients. We performed a prospective observational study and found complement activation-related pseudoallergy (CARPA) responsible in those with infusion reactions.

摘要

与脂质体两性霉素B相关的输注反应（心动过速、高血压、发热等）很常见。动物模型发现补体激活是其原因，但尚未在人类患者中评估其病理生理学。我们进行了一项前瞻性观察研究，发现补体激活相关的假过敏反应（CARPA）是发生输注反应患者的病因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03bd/11881558/d5e4f5c93eb8/aac.01692-24.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03bd/11881558/d5e4f5c93eb8/aac.01692-24.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03bd/11881558/d5e4f5c93eb8/aac.01692-24.f001.jpg

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引用本文的文献

[1]
Co-Encapsulation of Multiple Antineoplastic Agents in Liposomes by Exploring Microfluidics.

Int J Mol Sci. 2025-4-17

本文引用的文献

[1]
Amphotericin-Associated Infusion-Related Reactions: A Narrative Review of Pre-Medications.

Clin Ther. 2021-10

[2]
Complement-mediated hypersensitivity reactions to an amphotericin B-containing lipid complex (Abelcet) in pediatric patients and anesthetized rats: Benefits of slow infusion.

Nanomedicine. 2021-6

[3]
Comparison of complement activation-related pseudoallergy in miniature and domestic pigs: foundation of a validatable immune toxicity model.

Nanomedicine. 2016-1-6

[4]
Does lipid emulsion reduce amphotericin B nephrotoxicity? A systematic review and meta-analysis.

Clin Infect Dis. 2012-4-5

[5]
Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: prediction and prevention.

Adv Drug Deliv Rev. 2011-7-14

[6]
Liposome-induced complement activation and related cardiopulmonary distress in pigs: factors promoting reactogenicity of Doxil and AmBisome.

Nanomedicine. 2011-6-24

[7]
Differential transcriptional profiles induced by amphotericin B formulations on human monocytes during response to hyphae of Aspergillus fumigatus.

Med Mycol. 2010-8-31

[8]
Immunocompromised hosts: immunopharmacology of modern antifungals.

Clin Infect Dis. 2008-7-15

[9]
Differential expression of cytokines and chemokines in human monocytes induced by lipid formulations of amphotericin B.

Antimicrob Agents Chemother. 2005-4

[10]
Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil): possible role in hypersensitivity reactions.

Ann Oncol. 2003-9

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