脂质体两性霉素B与补体激活相关的假过敏反应（CARPA）。
Liposomal amphotericin B and complement activation-related pseudoallergy (CARPA).
作者信息
Thompson George R, Sani Gelina M, Donnelley Monica A, Figueroa Jaimie K, Ciuffetelli Ryan, Trigg Kate, Arredondo Juan, Koff Alan, Nearing Marie, Loque Ikaika C, Bays Derek J, Dandekar Satya
机构信息
Department of Internal Medicine, Division of Infectious Diseases, University of California-Davis Medical Center, Sacramento, California, USA.
Department of Medical Microbiology and Immunology, University of California-Davis, Davis, California, USA.
出版信息
Antimicrob Agents Chemother. 2025 Mar 5;69(3):e0169224. doi: 10.1128/aac.01692-24. Epub 2025 Jan 30.
Infusion reactions (tachycardia, hypertension, fever, etc.) associated with liposomal amphotericin B are common. Animal models have found complement activation responsible, yet the pathophysiology has not been evaluated in human patients. We performed a prospective observational study and found complement activation-related pseudoallergy (CARPA) responsible in those with infusion reactions.
与脂质体两性霉素B相关的输注反应（心动过速、高血压、发热等）很常见。动物模型发现补体激活是其原因，但尚未在人类患者中评估其病理生理学。我们进行了一项前瞻性观察研究，发现补体激活相关的假过敏反应（CARPA）是发生输注反应患者的病因。
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