Milosevits Gergely, Mészáros Tamás, Őrfi Erik, Bakos Tamás, Garami Miklós, Kovács Gábor, Dézsi László, Hamar Péter, Győrffy Balázs, Szabó András, Szénási Gábor, Szebeni János
Second Department of Paediatrics, Semmelweis University, Budapest, Hungary; Institute of Translational Medicine, Semmelweis University, Budapest, Hungary.
Institute of Translational Medicine, Semmelweis University, Budapest, Hungary; SeroScience LCC, Budapest, Hungary.
Nanomedicine. 2021 Jun;34:102366. doi: 10.1016/j.nano.2021.102366. Epub 2021 Feb 5.
Intravenous administration of lipid-based nanodrugs can cause hypersensitivity, also known as infusion reactions (IRs), that can be attenuated by slow infusion in adult patients. We studied the role of infusion rate and complement (C) activation in IRs in pediatric patients treated with Abelcet, and also in anesthetized rats. IRs were observed in 6 out of 10 (60%) patients who received Abelcet infusion in 4 h or less, while no patients who received the infusion in 6 h showed C activation or IRs. The rat model indicated an inverse relationship between infusion speed and Abelcet-induced hypotension, taken as an experimental endpoint of IRs, while the rise of C3a in blood, an index of C activation, directly correlated with hypotension. The results suggest that pediatric patients are more prone to produce IRs, and that the optimal infusion time of Abelcet may be much longer than the presently recommended 2 h.
静脉注射脂质纳米药物可引发超敏反应，也称为输液反应（IRs），在成年患者中，缓慢输注可减轻这种反应。我们研究了输注速率和补体（C）激活在接受阿贝西普治疗的儿科患者以及麻醉大鼠的输液反应中的作用。在10名在4小时或更短时间内接受阿贝西普输注的患者中，有6名（60%）出现了输液反应，而在6小时内接受输注的患者中，没有患者出现补体激活或输液反应。大鼠模型表明，输注速度与阿贝西普诱导的低血压之间呈负相关，低血压被视为输液反应的实验终点，而血液中C3a的升高（补体激活的指标）与低血压直接相关。结果表明，儿科患者更容易产生输液反应，阿贝西普的最佳输注时间可能比目前推荐的2小时长得多。
