Adel Domínguez Moises Abraham, Cardona Maya Walter D, Mora Topete Andrés
Centro de Uro-Andrología S.C., Guadalajara, Jalisco.
Grupo Reproducción, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Antioquia, Medellín.
Arch Ital Urol Androl. 2025 Mar 28;97(1):13128. doi: 10.4081/aiua.2025.13128. Epub 2025 Jan 30.
To determine the effects of oral antibiotics and anti-inflammatory agents on semen parameters and the sperm DNA fragmentation index (DFI).
Ninety-eight men with infertility diagnosis were included. The participants submitted two semen samples, before and at least two months after treatment. Macroscopic and microscopic semen parameters were evaluated following the World Health Organization (WHO) guidelines. In addition, the sperm DFI was evaluated using the sperm chromatin dispersion (SCD) technique. Subsequently, a treatment regimen was administered, including daily oral doses of ciprofloxacin (1000 mg) and doxycycline (100 mg) for 21 and 10 days, respectively. In addition, non-steroidal anti-inflammatory drugs (15 mg of meloxicam) were used for 10 days. After treatment, the same parameters were re-evaluated for new semen samples taken under the same initial conditions.
After treatment, significant increases in pH, sperm count, total concentration, and normal sperm morphology were observed, but no significant differences were found in the seminal volume parameter or progressive motility. After treatment, a significant decrease in the concentration of immature cells was observed, and although not statistically significant, a reduction in the concentration of leucocytes was observed. After treatment, the mean sperm DFI significantly decreased from 28.24± 2.39% to 16.2±7.1%.
Treatment with antibiotics and anti-inflammatories significantly reduced the sperm DFI and improved semen quality.
确定口服抗生素和抗炎药对精液参数及精子DNA碎片指数（DFI）的影响。
纳入98例诊断为不育症的男性。参与者在治疗前和治疗后至少两个月提交两份精液样本。按照世界卫生组织（WHO）指南评估精液的宏观和微观参数。此外，使用精子染色质扩散（SCD）技术评估精子DFI。随后，给予治疗方案，包括分别每日口服环丙沙星（1000毫克）和强力霉素（100毫克），疗程分别为21天和10天。此外，使用非甾体抗炎药（美洛昔康15毫克），疗程为10天。治疗后，对在相同初始条件下采集的新精液样本重新评估相同参数。
治疗后，观察到pH值、精子数量、总浓度和正常精子形态显著增加，但精液体积参数或前向运动能力未发现显著差异。治疗后，未成熟细胞浓度显著降低，白细胞浓度虽无统计学意义但有所下降。治疗后，精子平均DFI从28.24±2.39%显著降至16.2±7.1%。
抗生素和抗炎药治疗可显著降低精子DFI并改善精液质量。
