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小鼠C4结合蛋白基因(C4BP)是否定位于H-2区域?

Does the mouse C4-binding protein gene (C4BP) map in the H-2 region?

作者信息

Rodríguez de Córdoba S, Ferreira A, Rubinstein P

出版信息

Immunogenetics. 1985;21(3):257-65. doi: 10.1007/BF00375378.

DOI:10.1007/BF00375378
PMID:3988321
Abstract

A previous study on the genetics of mouse C4-binding protein (C4-bp) indicated the existence of a genetic polymorphism. Two genetic variants were reported and their segregation used to determine the mapping position of the C4BP locus to the H-2D-Qa interval of the mouse H-2 system. We show here, however, that purified C4-bp does not display the previously reported polymorphism. The mapping position of C4BP in the mouse therefore remains undetermined.

摘要

先前一项关于小鼠C4结合蛋白(C4-bp)遗传学的研究表明存在基因多态性。报告了两种基因变体,并利用它们的分离情况来确定C4BP基因座在小鼠H-2系统的H-2D-Qa区间的定位。然而,我们在此表明,纯化的C4-bp并未显示出先前报道的多态性。因此,小鼠中C4BP的定位仍然未确定。

相似文献

1
Does the mouse C4-binding protein gene (C4BP) map in the H-2 region?小鼠C4结合蛋白基因(C4BP)是否定位于H-2区域?
Immunogenetics. 1985;21(3):257-65. doi: 10.1007/BF00375378.
2
Murine binding protein of the fourth component of complement: structural polymorphism and its linkage to the major histocompatibility complex.补体第四成分的小鼠结合蛋白:结构多态性及其与主要组织相容性复合体的连锁关系。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3794-8. doi: 10.1073/pnas.78.6.3794.
3
Genetic mapping of mouse C4-bp locus to the H-2D-Qa interval.小鼠C4结合蛋白基因座的遗传定位至H-2D-Qa区间。
J Immunol. 1984 Jan;132(1):6-8.
4
The molecular genetics of components of complement.补体成分的分子遗传学
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J Exp Med. 1985 May 1;161(5):1189-95. doi: 10.1084/jem.161.5.1189.
6
Genetic polymorphism of human C4-binding protein.人类C4结合蛋白的基因多态性
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The binding site of human C4b-binding protein on complement C4 is localized in the alpha'-chain.人C4b结合蛋白在补体C4上的结合位点定位于α'-链。
J Immunol. 1990 Apr 1;144(7):2632-7.
8
Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.补体C4的α3片段与C4b结合蛋白结合的重要性。
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Evidence for linkage between the loci coding for the binding protein for the fourth component of human complement (C4BP) and for the C3b/C4b receptor.编码人补体第四成分(C4BP)结合蛋白的基因座与C3b/C4b受体之间存在连锁关系的证据。
Proc Natl Acad Sci U S A. 1984 Dec;81(24):7890-2. doi: 10.1073/pnas.81.24.7890.
10
Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.对Eα和C4基因之间存在交叉的H-2重组小鼠品系进行限制性片段分析。
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本文引用的文献

1
THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.高比放射性碘-131标记人生长激素的制备
Biochem J. 1963 Oct;89(1):114-23. doi: 10.1042/bj0890114.
2
A simplified two-dimensional electrophoretic technique.一种简化的二维电泳技术。
J Immunol Methods. 1981;43(3):291-9. doi: 10.1016/0022-1759(81)90177-0.
3
Assignment of the structural gene for the third component of human complement to chromosome 19.人类补体第三成分结构基因定位于19号染色体。
Proc Natl Acad Sci U S A. 1982 Aug;79(16):5021-5. doi: 10.1073/pnas.79.16.5021.
4
Murine binding protein of the fourth component of complement: structural polymorphism and its linkage to the major histocompatibility complex.补体第四成分的小鼠结合蛋白:结构多态性及其与主要组织相容性复合体的连锁关系。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3794-8. doi: 10.1073/pnas.78.6.3794.
5
Genetic polymorphism of human C4-binding protein.人类C4结合蛋白的基因多态性
J Immunol. 1983 Sep;131(3):1565-9.
6
The genetics of the sixth and seventh components of complement in the dog: polymorphism, linkage, locus duplication, and silent alleles.犬补体第六和第七成分的遗传学:多态性、连锁、基因座重复及沉默等位基因
Biochem Genet. 1983 Feb;21(1-2):81-91. doi: 10.1007/BF02395393.
7
Genetic mapping of mouse C4-bp locus to the H-2D-Qa interval.小鼠C4结合蛋白基因座的遗传定位至H-2D-Qa区间。
J Immunol. 1984 Jan;132(1):6-8.
8
Genetics and linkage relationships of the C3 polymorphism: discovery of C3-Se linkage and assignment of LES-C3-DM-Se-PEPD-Lu synteny to chromosome 19.C3多态性的遗传学及连锁关系:C3与硒(Se)的连锁发现以及LES-C3-DM-Se-PEPD-Lu同线性群在19号染色体上的定位
Clin Genet. 1983 Sep;24(3):159-70. doi: 10.1111/j.1399-0004.1983.tb02233.x.
9
Polymorphism of human erythrocyte C3b/C4b receptor.人类红细胞C3b/C4b受体的多态性
Proc Natl Acad Sci U S A. 1983 Mar;80(6):1698-702. doi: 10.1073/pnas.80.6.1698.
10
High molecular weight complex in human plasma between vitamin K-dependent protein S and complement component C4b-binding protein.人血浆中维生素K依赖蛋白S与补体成分C4b结合蛋白之间的高分子量复合物。
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2512-6. doi: 10.1073/pnas.78.4.2512.