Cevher Selim, Üçer Mehmet Barış, Öztürk Caner
Department of Ophthalmology, Faculty of Medicine, Hitit University, 019040, Çorum, Turkey.
Sincan Training and Research Hospital, Ankara, Turkey.
Int Ophthalmol. 2025 Jan 24;45(1):38. doi: 10.1007/s10792-025-03408-6.
To examine the detailed vascular and morphological characteristics of the choroidal tissue in subjects with myopia.
A total of 111 subjects with myopia were included in the study. The study was conducted in three groups according to spherical equivalent(SE). Group 1 comprised subjects with low myopia (SE between 0.00 diopter (D) and - 3.00 D), Group 2 included those with moderate myopia (SE between - 3.25 D and - 6.00 D), and Group 3 consisted of subjects with high myopia (SE of - 6.25 D or worse). The following parameters were measured: axial length(AL), SE, central macular thickness (CMT), choroidal thickness(CT), total choroidal area(TCA), luminal area(LA), stromal area(SA), LA/SA ratio, and choroidal vascularity index(CVI). The binarization method was employed to calculate the TCA, LA, SA, LA/SA ratio, and CVI values. A comparison was conducted between the groups with respect to all parameters.
In patients with high myopia, CT values (subfoveal, nasal, and temporal) were significantly thinner than moderate and low myopic patients (< 0.001). The low myopic group exhibited significantly elevated LA, SA, and TCA values in comparison to the moderate and high myopic groups. Conversely, the LA/SA ratio and CVI values were observed to be higher in patients with high myopia than in those with low or moderate myopia. A statistically significant negative correlation was identified between CVI and LA/SA values and SE(r = - 0.270, P = 0.004; r = - 0.291, P = 0.002, respectively). A statistically significant positive correlation was identified between CVI and LA/SA values and AL (r = 0.269, P = 0.004; r = 0.281, P = 0.003, respectively).
In young adults, high myopia has been linked to significant choroidal thinning in the macular region. This reduction in choroidal thickness is largely attributed to a decrease in the stromal component of the choroid, rather than the luminal (vascular) component.
08/06/2022, 2022-49.
研究近视患者脉络膜组织详细的血管和形态特征。
本研究共纳入111例近视患者。根据等效球镜度（SE）将研究对象分为三组。第1组为低度近视患者（SE在0.00屈光度（D）至-3.00 D之间），第2组包括中度近视患者（SE在-3.25 D至-6.00 D之间），第3组为高度近视患者（SE为-6.25 D或更低）。测量以下参数：眼轴长度（AL）、SE、中心黄斑厚度（CMT）、脉络膜厚度（CT）、脉络膜总面积（TCA）、管腔面积（LA）、基质面积（SA）、LA/SA比值以及脉络膜血管指数（CVI）。采用二值化方法计算TCA、LA、SA、LA/SA比值和CVI值。对所有参数在三组之间进行比较。
高度近视患者的CT值（黄斑中心凹下、鼻侧和颞侧）显著薄于中度和低度近视患者（<0.001）。与中度和高度近视组相比，低度近视组的LA、SA和TCA值显著升高。相反，高度近视患者的LA/SA比值和CVI值高于低度或中度近视患者。CVI与LA/SA值及SE之间存在显著的负相关（r = -0.270，P = 0.004；r = -0.291，P = 0.002）。CVI与LA/SA值及AL之间存在显著的正相关（r = 0.269，P = 0.004；r = 0.281，P = 0.003）。
在年轻成年人中，高度近视与黄斑区脉络膜显著变薄有关。脉络膜厚度的这种降低在很大程度上归因于脉络膜基质成分的减少，而非管腔（血管）成分的减少。
2022年6月8日，2022-49。
