Zheng Ming
Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, China; Academy of Military Medical Sciences, 27 Taiping Road, Beijing 100850, China.
Eur Neuropsychopharmacol. 2025 Apr;93:19-21. doi: 10.1016/j.euroneuro.2025.01.002. Epub 2025 Jan 29.
Parkinson's disease (PD), once viewed as a neurodegenerative disorder, is now increasingly recognized as part of a broader disease continuum, intricately linked to comorbidities across various organ systems. This study provides a snapshot of the disease continuum centered on PD, using a disease-wide association study (DWAS) involving 392,423 individuals-including 4,235 PD cases. This DWAS identifies disease clusters of PD comorbidities across the musculoskeletal, circulatory, digestive, and respiratory systems. Moreover, comorbidities were classified based on their temporal relationship to PD diagnosis: pre-PD comorbidities, such as hypertension and autoimmune disorders, may act as risk factors of PD onset, while post-PD comorbidities, including Alzheimer's disease and renal disorders, highlight the systemic consequences of PD progression. These findings emphasize the critical need for early detection and intervention to manage comorbidities and potentially delay PD onset. Furthermore, this study advocates for integrated diagnostic and therapeutic strategies targeting shared risk factors, advancing a precision-medicine approach to improve patient care and long-term management of PD.
帕金森病（PD）曾被视为一种神经退行性疾病，如今越来越被认为是更广泛疾病连续体的一部分，与各个器官系统的合并症有着复杂的联系。本研究通过一项涵盖392423人（包括4235例PD病例）的全疾病关联研究（DWAS），提供了以PD为中心的疾病连续体的概况。该DWAS确定了PD在肌肉骨骼、循环、消化和呼吸系统合并症的疾病集群。此外，合并症根据其与PD诊断的时间关系进行分类：PD前合并症，如高血压和自身免疫性疾病，可能是PD发病的危险因素，而PD后合并症，包括阿尔茨海默病和肾脏疾病，则突出了PD进展的全身后果。这些发现强调了早期检测和干预以管理合并症并可能延迟PD发病的迫切需求。此外，本研究提倡针对共同危险因素的综合诊断和治疗策略，推进精准医学方法以改善PD患者的护理和长期管理。
