Kurnik P B, Tiefenbrunn A J, Ludbrook P A
Invest Radiol. 1985 Mar-Apr;20(2):203-11. doi: 10.1097/00004424-198503000-00020.
The effects of intraventricular and intracoronary contrast media on the peripheral arterial and venous beds were directly measured with forearm plethysmography. Standard dose intraventricular radiographic contrast produces a potent peripheral arterial vasodilator effect accompanied by a hypotensive and tachycardic response, followed by peripheral venoconstriction, suggesting that the net hemodynamic response is mediated peripherally. Coronary arteriography is associated with a differing pattern of response, suggesting that the most important hemodynamic effects are mediated via myocardial depression with secondary peripheral vascular responses. Hemodynamic changes occur earlier than those following ventriculography and reflect peripheral arterial and venous constriction. Dose and osmolarity of the contrast are important determinants as well as the site of administration.
采用前臂体积描记法直接测量脑室内和冠状动脉内造影剂对外周动脉和静脉床的影响。标准剂量的脑室内放射造影剂可产生强效的外周动脉血管舒张作用，并伴有低血压和心动过速反应，随后出现外周静脉收缩，提示净血流动力学反应是由外周介导的。冠状动脉造影与不同的反应模式相关，提示最重要的血流动力学效应是通过心肌抑制介导，并伴有继发性外周血管反应。血流动力学变化比脑室造影后出现得更早，反映外周动脉和静脉收缩。造影剂的剂量、渗透压以及给药部位都是重要的决定因素。
