Luo Shouling, Zhang Xiaoyue, Liu Zhenzhen, Wang Chengjie, Pei Jiangnan, Yu Yi, Liu Haiyan, Gu Weirong
The Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, 419 Fangxie Road, Huangpu Area, Shanghai, 200011, China.
Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China.
BMC Pregnancy Childbirth. 2025 Jan 30;25(1):98. doi: 10.1186/s12884-025-07183-1.
The objective of this study was to investigate the efficacy of low-dose aspirin (LDA) in preventing preeclampsia among pregnant women with polycystic ovary syndrome (PCOS), given the increased susceptibility of this population to preeclampsia development.
A retrospective cohort study was conducted on pregnant women with PCOS who delivered between January 1, 2018 and February 10, 2024 at our institution. Clinical characteristics and obstetric data were extracted from medical records. Propensity score matching (PSM) was employed to analyze the association between LDA use and PE incidence.
The study cohort comprised 1522 pregnant women with PCOS. Among 395 pregnant women identified as high-risk for preeclampsia, 98 were administered LDA for preeclampsia prevention, while 297 did not receive LDA. Following PSM, no statistically significant difference was observed in preeclampsia risk between the LDA and non-LDA groups. Additionally, maternal and neonatal outcomes were comparable between the two groups.
This cohort analysis did not provide sufficient evidence to support the efficacy of LDA in preventing preeclampsia among PCOS patients at high risk for preeclampsia.
鉴于多囊卵巢综合征（PCOS）患者患先兆子痫的易感性增加，本研究的目的是探讨低剂量阿司匹林（LDA）在预防PCOS孕妇先兆子痫方面的疗效。
对2018年1月1日至2024年2月10日在我院分娩的PCOS孕妇进行回顾性队列研究。从病历中提取临床特征和产科数据。采用倾向评分匹配（PSM）分析LDA使用与先兆子痫发生率之间的关联。
研究队列包括1522例PCOS孕妇。在395例被确定为先兆子痫高危的孕妇中，98例接受LDA预防先兆子痫，297例未接受LDA。PSM后，LDA组和非LDA组之间的先兆子痫风险无统计学显著差异。此外，两组的母婴结局相当。
这项队列分析没有提供足够的证据支持LDA在预防先兆子痫高危PCOS患者先兆子痫方面的疗效。
