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测量近距离放射治疗中患者报告的结局:我们为何要这样做,更重要的是如何去做。

Measuring patient reported outcomes in brachytherapy: Why we should do it and more importantly how.

作者信息

Spyrou Aspazia, Martin André-Guy, Hannoun-Lévi Jean-Michel, Stewart Alexandra

机构信息

Royal Surrey Hospital, Guildford, UK.

Centre Intégré de Cancérologie, CHU de Québec - Université Laval, Quebec, Canada.

出版信息

Clin Transl Radiat Oncol. 2024 Oct 2;49:100870. doi: 10.1016/j.ctro.2024.100870. eCollection 2024 Nov.

Abstract

As the treatment for cancer improves and advances are made, the clinical focus is often on treatment response and survival. However, these are not the only factors which are important to patients. More patients are living longer after cancer treatment and therefore it is important that we can describe not only the treatment to patients but also what their life will be like during and after treatment. Patient reported outcomes (PROs) allow us to describe these. Although there are a range of patient reported outcome measures (PROMs) available to the clinician to assess these, the use of them in many areas of brachytherapy lags behind ideal levels. Brachytherapy has many features that differ to external beam radiotherapy (EBRT) yet the assessment of quality of life during and after treatment is much more scarce than EBRT. Brachytherapy is often used in the setting of organ preservation or in place of radical surgery, yet there is a paucity of quality of life data comparing the different treatment modalities. This review article will aim to elaborate on the evidence that exists in the use of specific PROMs within prostate, breast and gynaecologic cancers and describe the development of a novel PROMs approach in rectal brachytherapy which aims to identify and resolve symptoms at an early stage.

摘要

随着癌症治疗方法的改进和进步,临床重点往往在于治疗反应和生存率。然而,这些并非对患者而言唯一重要的因素。越来越多的患者在癌症治疗后存活时间更长,因此,我们不仅要向患者描述治疗方法,还要说明他们在治疗期间及治疗后的生活状况,这一点很重要。患者报告结局(PROs)使我们能够描述这些情况。尽管临床医生有一系列患者报告结局测量工具(PROMs)可用于评估这些情况,但在近距离放射治疗的许多领域,这些工具的使用仍落后于理想水平。近距离放射治疗有许多与外照射放疗(EBRT)不同的特点,然而,与EBRT相比,治疗期间及治疗后的生活质量评估却少得多。近距离放射治疗常用于器官保留或替代根治性手术的情况,但比较不同治疗方式的生活质量数据却很匮乏。这篇综述文章旨在详细阐述前列腺癌、乳腺癌和妇科癌症中使用特定PROMs的现有证据,并描述直肠近距离放射治疗中一种新型PROMs方法的发展,该方法旨在早期识别和解决症状。

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