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通过负载α-乙酰半胱氨酸和赖氨酸的水凝胶阻断皮肤致敏的不良结局途径。

Blocking the adverse outcome pathway of skin sensitization through a -acetyl cysteine and lysine-loaded hydrogel.

作者信息

Brites Gonçalo S, Ferreira Isabel, Sebastião Ana I, Sousa Cátia, Silva Ana, Carrascal Mylene, Oliveira Rui C, Gonçalo Margarida, Vitorino Carla, Neves Bruno M, Cruz Maria T

机构信息

Faculty of Pharmacy, University of Coimbra, 3000-548, Coimbra, Portugal.

Toxfinder, Lda, IPN - Instituto Pedro Nunes, 3030-199, Coimbra, Portugal.

出版信息

J Pharm Anal. 2025 Jan;15(1):101071. doi: 10.1016/j.jpha.2024.101071. Epub 2024 Aug 14.

DOI:10.1016/j.jpha.2024.101071
PMID:39885970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11780087/
Abstract

Image 1.

摘要

图1。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcd6/11780087/614b1f213ac0/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcd6/11780087/d4c444e6a7fd/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcd6/11780087/614b1f213ac0/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcd6/11780087/d4c444e6a7fd/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcd6/11780087/614b1f213ac0/gr1.jpg

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本文引用的文献

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Development of an in chemico high-throughput screening method for the identification of skin sensitization potential.开发一种用于鉴定皮肤致敏潜力的化学高通量筛选方法。
Arch Toxicol. 2023 Sep;97(9):2441-2451. doi: 10.1007/s00204-023-03550-z. Epub 2023 Jul 19.
2
Development of a new hydrogel for the prevention of allergic contact dermatitis.新型水凝胶预防变应性接触性皮炎的研制。
Int J Pharm. 2022 Nov 25;628:122265. doi: 10.1016/j.ijpharm.2022.122265. Epub 2022 Oct 8.
3
Prevalence of most common skin diseases in Europe: a population-based study.
欧洲最常见皮肤病的患病率：一项基于人群的研究。
J Eur Acad Dermatol Venereol. 2022 Jul;36(7):1088-1096. doi: 10.1111/jdv.18050. Epub 2022 Mar 22.
4
Novel insights into contact dermatitis.接触性皮炎的新见解。
J Allergy Clin Immunol. 2022 Apr;149(4):1162-1171. doi: 10.1016/j.jaci.2022.02.002. Epub 2022 Feb 18.