Fernandez-Martin Pedro, Gaitan-Roman Daniel, Martinez-Esteban Maria Dolores, Fernandez-Ruz Leopoldo, Larrubia-Valle Jose Ignacio, Delgado-Prieto Jose Luis, Urbano-Carrillo Cristobal Antonio
Department of Cardiology, Málaga Regional University Hospital, Málaga, Spain.
JACC Case Rep. 2025 Jan 15;30(2):102812. doi: 10.1016/j.jaccas.2024.102812.
Pickering syndrome, characterized by recurrent episodes of flash pulmonary edema (FPE) and renal impairment, is associated with renal artery stenosis (RAS). This case highlights its manifestation and management in an older adult patient. An 86-year-old woman with hypertension, chronic kidney disease, and a single functioning kidney presented with recurrent FPE episodes. Imaging revealed severe left RAS and an atrophic right kidney. Despite initial medical management, recurrent episodes of pulmonary edema led to renal angioplasty with stent placement. Follow-up imaging revealed restenosis in the left renal artery, necessitating a second angioplasty. The patient's condition stabilized after intervention, with improvement in both cardiac and renal function. This case illustrates the critical importance of considering RAS in patients with recurrent FPE and resistant hypertension and emphasizes timely diagnosis and intervention. Early detection and intervention in Pickering syndrome can prevent recurrent pulmonary edema and renal failure.
皮克林综合征以反复发生的急性肺水肿(FPE)和肾功能损害为特征,与肾动脉狭窄(RAS)相关。本病例突出了其在老年患者中的表现及管理。一名患有高血压、慢性肾脏病且仅有一个功能肾的86岁女性出现反复急性肺水肿发作。影像学检查显示左肾动脉严重狭窄及右肾萎缩。尽管初始进行了药物治疗,但肺水肿反复发作导致进行了肾血管成形术并置入支架。随访影像学检查显示左肾动脉再狭窄,需要进行第二次血管成形术。干预后患者病情稳定,心脏和肾功能均有改善。本病例说明了在反复发生急性肺水肿和顽固性高血压患者中考虑肾动脉狭窄的至关重要性,并强调了及时诊断和干预。皮克林综合征的早期检测和干预可预防反复肺水肿和肾衰竭。