Chang Xinyue, Yang Pinni, Liu Yi, He Yu, Qin Xiaoli, Song Beiping, Yu Quan, Fei Jiawen, Shi Mengyao, Guo Daoxia, Peng Yanbo, Chen Jing, Wang Aili, Xu Tan, He Jiang, Zhang Yonghong, Zhu Zhengbao
Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Curr Neurovasc Res. 2025;21(5):545-553. doi: 10.2174/0115672026368528250113080256.
Plasma osteoprotegerin (OPG) has been linked to poor prognosis following stroke, but its impact on post-stroke cognitive impairment (PSCI) is unknown. The purpose of our work was to analyze the relationship of OPG with PSCI.
Our study included 613 ischemic stroke subjects with plasma OPG levels. We used the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) to assess PSCI. PSCI was defined as MMSE score <25 or MoCA score <23.
As assessed by the MMSE score, the adjusted odds ratio for PSCI in the highest OPG tertile was 1.77, with a 95% confidence interval of 1.09 to 2.89 (P=0.021), compared to that in the lowest tertile. We observed a positive linear relationship of plasma OPG levels with 3- month PSCI (P for linearity=0.046). Incorporating plasma OPG into conventional risk factors enhanced PSCI risk reclassification (all P <0.05). Consistent results were discovered when PSCI was evaluated using the MoCA score.
High plasma OPG levels were related to an elevated risk of 3-month PSCI, indicating that OPG might be an effective biomarker for predicting PSCI.
血浆骨保护素（OPG）与中风后预后不良有关，但其对中风后认知障碍（PSCI）的影响尚不清楚。我们研究的目的是分析OPG与PSCI之间的关系。
我们的研究纳入了613名有血浆OPG水平的缺血性中风患者。我们使用简易精神状态检查表（MMSE）和蒙特利尔认知评估量表（MoCA）来评估PSCI。PSCI定义为MMSE评分<25或MoCA评分<23。
以MMSE评分评估，与最低三分位数相比，最高OPG三分位数中PSCI的校正比值比为1.77，95%置信区间为1.09至2.89（P=0.021）。我们观察到血浆OPG水平与3个月时的PSCI呈正线性关系（线性P=0.046）。将血浆OPG纳入传统危险因素可增强PSCI风险重新分类（所有P<0.05）。使用MoCA评分评估PSCI时发现了一致的结果。
血浆OPG水平升高与3个月时PSCI风险升高有关，表明OPG可能是预测PSCI的有效生物标志物。
