Lei Shuning, Luo Min, Wang Yuxue
Department of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China.
Mol Med Rep. 2025 Mar;31(3). doi: 10.3892/mmr.2025.13445. Epub 2025 Jan 31.
Peptidyl‑prolyl cis‑trans isomerase NIMA-interacting 1 (Pin1) is a specific phosphorylated serine/threonine-proline cis-trans isomerase, which is involved in the regulation of a variety of physiological and pathological processes, including cell cycle progression, proliferation and apoptosis. Pin1 plays a key role in tumorigenesis and tumor development and it promotes the proliferation and metastasis of cancer cells by regulating the cell cycle, signaling pathways and the function of tumor suppressors. Upregulated expression of Pin1 is closely associated with a poor prognosis in several types of cancers. Thus, Pin1 is may have potential as a novel potential biomarker for tumor diagnosis and prognosis, as well as a promising anticancer target. The aim of the present review was to discuss the mechanism of Pin1 in tumors and recent research progress in this field.
肽基脯氨酰顺反异构酶NIMA相互作用蛋白1（Pin1）是一种特异性磷酸化的丝氨酸/苏氨酸-脯氨酸顺反异构酶，参与多种生理和病理过程的调控，包括细胞周期进程、增殖和凋亡。Pin1在肿瘤发生和发展中起关键作用，它通过调节细胞周期、信号通路和肿瘤抑制因子的功能来促进癌细胞的增殖和转移。Pin1的表达上调与多种癌症的不良预后密切相关。因此，Pin1可能具有作为肿瘤诊断和预后的新型潜在生物标志物以及有前景的抗癌靶点的潜力。本综述的目的是探讨Pin1在肿瘤中的作用机制以及该领域的最新研究进展。
