Kocerha Jannet, Denslow Nancy D
J Endocrinol. 2025 Feb 17;265(1). doi: 10.1530/JOE-24-0232. Print 2025 Apr 1.
The importance of steroidogenesis is underscored by its vital and conserved functions from higher to lower vertebrate species, such as stress, immune and inflammatory responses, sexual development and reproduction, osmoregulation and even the ability to adapt to the environment and environmental changes. Correspondingly, the rate-limiting step of steroidogenesis mediated by the steroidogenic acute regulatory protein is an ongoing target for scientific investigation. An expanding collection of studies has now reported key similarities, as well as some differences, in the transcriptional and translational regulation of steroidogenic acute regulatory protein across species. This review will discuss the current understanding of steroidogenic acute regulatory protein in fish, as these lower vertebrate models uniquely rely on steroid hormones for osmotic balance, reproductive functions, responses to environmental stimuli and much more.
类固醇生成的重要性体现在其在从高等到低等脊椎动物物种中至关重要且保守的功能上，如应激、免疫和炎症反应、性发育和繁殖、渗透压调节，甚至适应环境及环境变化的能力。相应地，由类固醇生成急性调节蛋白介导的类固醇生成限速步骤一直是科学研究的目标。现在越来越多的研究报告了跨物种类固醇生成急性调节蛋白在转录和翻译调控方面的关键相似之处以及一些差异。本综述将讨论目前对鱼类类固醇生成急性调节蛋白的理解，因为这些低等脊椎动物模型独特地依赖类固醇激素来维持渗透压平衡、生殖功能、对环境刺激的反应等等。
