有色人种儿童患者的皮肤肥大细胞增多症：一项回顾性队列研究。
Cutaneous Mastocytosis in Pediatric Patients With Skin of Color: A Retrospective Cohort Study.
作者信息
Walker Trent D, Varra Vamsi, Fosu Nana, Paradiso Michela, Mosser-Goldfarb Joy
机构信息
Transitional Year at BayCare Health System, Florida State University College of Medicine, Winter Haven, Florida, USA.
Division of Dermatology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
出版信息
Pediatr Dermatol. 2025 Jan 31;42(4):793-5. doi: 10.1111/pde.15881.
Cutaneous mastocytosis (CM) is a rare skin disease with limited data on its prevalence across different racial groups. This retrospective cohort study examines the characteristics of CM at Nationwide Children's Hospital (NCH) from January 2010 to June 2022, identifying 192 confirmed cases of CM and further stratifying this cohort to 155 patients with documented Fitzpatrick phototypes. There were two important findings: first, nine (4.7%) of the CM cases were Black and 165 (85.9%) were White, compared to 8502 (23.0%) Black and 21,177 (57.3%) White of the overall NCH dermatology population; second, 85.8% were Fitzpatrick phototypes I-III, and 14.9% were types IV-VI with no significant differences, other than types IV-VI being more likely to receive treatment (p = 0.01). Our study highlights the need to better understand the genetics and other risk factors of CM, as well as the social determinants of health impacting pediatric patients with skin of color.
皮肤肥大细胞增多症（CM）是一种罕见的皮肤病，关于其在不同种族群体中的患病率的数据有限。这项回顾性队列研究调查了2010年1月至2022年6月期间全国儿童医院（NCH）的CM特征，确定了192例确诊的CM病例，并将该队列进一步分层为155例有记录的菲茨帕特里克皮肤分型的患者。有两个重要发现：第一，CM病例中9例（4.7%）为黑人，165例（85.9%）为白人，而NCH皮肤科总体人群中黑人有8502例（23.0%），白人有21177例（57.3%）；第二，85.8%为菲茨帕特里克皮肤分型I - III型，14.9%为IV - VI型，除IV - VI型更有可能接受治疗外（p = 0.01），无显著差异。我们的研究强调需要更好地了解CM的遗传学和其他风险因素，以及影响有色人种儿科患者的健康的社会决定因素。
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