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The physiological impact of an N-terminal Halo-tag on glucose-dependent insulinotropic polypeptide receptor function in mice.

作者信息

Davies Iona, Manchanda Yusman, Sloop Kyle W, Bloom Stephen R, Tan Tricia M-M, Tomas Alejandra, Jones Ben

机构信息

Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.

Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.

出版信息

Diabetes Obes Metab. 2025 Apr;27(4):2294-2298. doi: 10.1111/dom.16216. Epub 2025 Jan 30.

DOI:10.1111/dom.16216
PMID:39888232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11885072/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43b0/11885072/80dc7421c804/DOM-27-2294-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43b0/11885072/633bba2dc8ab/DOM-27-2294-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43b0/11885072/80dc7421c804/DOM-27-2294-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43b0/11885072/633bba2dc8ab/DOM-27-2294-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43b0/11885072/80dc7421c804/DOM-27-2294-g002.jpg

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本文引用的文献

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RSC Chem Biol. 2024 Nov 18;6(1):11-20. doi: 10.1039/d4cb00209a. eCollection 2025 Jan 2.
2
Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor.替尔泊肽通过长效激活 GIP 受体调节脂肪细胞营养代谢的调节。
Cell Metab. 2024 Jul 2;36(7):1534-1549.e7. doi: 10.1016/j.cmet.2024.05.010. Epub 2024 Jun 14.
3
Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding.
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JCI Insight. 2023 May 22;8(10):e164921. doi: 10.1172/jci.insight.164921.
4
Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells.增强的内体信号和胰腺β细胞中 GLP-1R 与 GIPR 的脱敏作用。
Endocrinology. 2023 Mar 13;164(5). doi: 10.1210/endocr/bqad028.
5
Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling.揭示内源性胰高血糖素样肽-1 受体表达和信号转导的组织水平复杂性。
Nat Commun. 2023 Jan 18;14(1):301. doi: 10.1038/s41467-022-35716-1.
6
GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue.GIPR 主要定位于白色脂肪组织中的非脂肪细胞类型。
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Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism.慢性葡萄糖依赖性胰岛素促分泌多肽受体（GIPR）激动剂作用脱敏可模拟功能性 GIPR 拮抗作用，使脂肪细胞 GIPR 活性降低。
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