Porter I D, Gardiner I M, de Belleroche J
J Cereb Blood Flow Metab. 1985 Jun;5(2):338-42. doi: 10.1038/jcbfm.1985.44.
The effect of the dihydropyridine nimodipine was studied on the resting and K+-evoked release of [3H]acetylcholine (ACh) and [3H]5-hydroxytryptamine (5HT) from postmortem human cerebral arteries. Nimodipine, at a concentration of 30 microM, significantly reduced the K+-evoked release of [3H]ACh from anterior and middle cerebral arteries by 36 and 70%, respectively, and the K+-evoked release of [3H]5HT from basilar and middle cerebral arteries by 55 and 66%, respectively. The mode of action of nimodipine is interpreted in terms of a specific effect on the depolarisation-induced calcium current occurring in neuronal elements present in these preparations but absent from brain.
研究了二氢吡啶尼莫地平对人死后脑动脉中[3H]乙酰胆碱（ACh）和[3H]5-羟色胺（5HT）静息释放及钾离子诱发释放的影响。浓度为30微摩尔的尼莫地平分别使大脑前动脉和大脑中动脉中钾离子诱发的[3H]ACh释放显著降低36%和70%，使基底动脉和大脑中动脉中钾离子诱发的[3H]5HT释放分别降低55%和66%。尼莫地平的作用方式被解释为对这些制剂中存在但大脑中不存在的神经元成分中去极化诱导的钙电流具有特异性作用。
