Zhang Yi, He Mu, Pan Junmin
MOE Key Laboratory of Protein Sciences，State Key Laboratory of Complex, Severe, and Rare Diseases, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao, China.
Biochem Soc Trans. 2025 Jan 31;53(1):BST20240688. doi: 10.1042/BST20240688.
Cilia and eukaryotic flagella (exchangeable terms) function in cell motility and signaling, which are pivotal for development and physiology. Cilia dysfunction can lead to ciliopathies. Cilia are usually assembled in quiescent and/or differentiated cells and undergo disassembly when cells enter cell cycle or in response to environmental stresses. Cilia contain a microtubule-based structure termed axoneme that comprises nine outer doublet microtubules with or without a pair of central microtubules, which is ensheathed by the ciliary membrane. Regulation of the axonemal microtubule dynamics is tightly associated with ciliary assembly and disassembly. In this short review, we discuss recent findings on the regulation of axonemal microtubules by microtubule-binding proteins and microtubule modulating kinesins during ciliary assembly and disassembly.
纤毛与真核生物鞭毛（可互换术语）在细胞运动和信号传导中发挥作用，这对发育和生理过程至关重要。纤毛功能障碍可导致纤毛病。纤毛通常在静止和/或分化细胞中组装，并在细胞进入细胞周期或响应环境应激时发生解聚。纤毛包含一种基于微管的结构，称为轴丝，它由九对外周双联微管组成，可有或没有一对中央微管，并被纤毛膜包裹。轴丝微管动力学的调节与纤毛的组装和解聚密切相关。在这篇简短的综述中，我们讨论了关于在纤毛组装和解聚过程中微管结合蛋白和微管调节驱动蛋白对轴丝微管调节的最新发现。
