碳青霉烯类耐药肺炎克雷伯菌治疗期间KPC-230介导的对头孢他啶-阿维巴坦耐药性的动态演变
Dynamic evolution of KPC-230-mediated resistance to ceftazidime-avibactam during the treatment of carbapenem-resistant Klebsiella pnenmoniae.
作者信息
Li Xi, Zhou Longjie, Huang Huaqiong
机构信息
Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.
Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
出版信息
Drug Resist Updat. 2025 Mar;79:101205. doi: 10.1016/j.drup.2025.101205. Epub 2025 Jan 25.
The molecular mechanisms driving the development of KPC-230-mediated resistance to ceftazidime-avibactam during treatment of carbapenem-resistant Klebsiella pneumoniae infection was elucidated by analyzing specimens collected from a patient, including one bla-positive and three bla-positive Klebsiella pnenmoniae isolates.
通过分析从一名患者收集的标本，包括一株bla阳性和三株bla阳性肺炎克雷伯菌分离株，阐明了在耐碳青霉烯类肺炎克雷伯菌感染治疗期间，KPC - 230介导的对头孢他啶 - 阿维巴坦耐药性发展的分子机制。
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