食管鳞状细胞癌患者淋巴结中高FOXP3状态的负面影响

Negative Impact of High FOXP3 Status in Lymph Nodes of Esophageal Squamous Cell Carcinoma Patients.

作者信息

Nonaka Yukiko, Baba Taisuke, Sugita Shizuki, Miyata Kazushi, Sunagawa Masaki, Yamaguchi Junpei, Kokuryo Toshio, Yokoyama Yukihiro, Ebata Tomoki

机构信息

Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan

出版信息

Anticancer Res. 2025 Feb;45(2):781-787. doi: 10.21873/anticanres.17466.

DOI:10.21873/anticanres.17466

PMID:39890167

Abstract

BACKGROUND/AIM: Available data on the immune profiles of regional lymph nodes in individuals with esophageal squamous cell carcinoma (ESCC) are limited. This study investigated the immune profiles of proximal regional lymph nodes (PLNs) and evaluated the association between PLNs and the outcomes of patients with ESCC.

PATIENTS AND METHODS

This study included 39 patients with ESCC who underwent subtotal esophagectomy with three-field lymph node dissection. The immune profiles of tumor-infiltrating lymphocytes and PLNs were evaluated through immunohistochemistry. Furthermore, the impact of this immune profile on long-term outcomes was analyzed.

RESULTS

Cox proportional-hazards analysis for overall survival revealed that ypT ≥3 [hazard ratio (HR)=8.91; 95% confidence interval (CI)=1.59-49.8] and high FOXP3 status in PLNs (HR=4.29; 95%CI=1.06-17.4) are significant independent prognostic factors. Meanwhile, analysis of disease-free survival (DFS) revealed that ypT ≥3 (HR=5.52; 95%CI=1.15-26.6) and ypN ≥1 (HR=7.74; 95%CI=1.58-37.9) are independent prognostic factors. Furthermore, high FOXP3 status in PLNs was associated with low DFS rate, although the association was not statistically significant (HR=1.70; 95%CI=0.58-5.02).

CONCLUSION

High FOXP3 status in PLNs is associated with poor prognosis in patients with ESCC.

摘要

背景/目的：关于食管鳞状细胞癌（ESCC）患者区域淋巴结免疫特征的现有数据有限。本研究调查了近端区域淋巴结（PLNs）的免疫特征，并评估了PLNs与ESCC患者预后之间的关联。

患者与方法

本研究纳入了39例行食管次全切除术并进行三野淋巴结清扫的ESCC患者。通过免疫组织化学评估肿瘤浸润淋巴细胞和PLNs的免疫特征。此外，分析了这种免疫特征对长期预后的影响。

结果

总生存的Cox比例风险分析显示，ypT≥3[风险比（HR）=8.91；95%置信区间（CI）=1.59 - 49.8]和PLNs中高FOXP3状态（HR = 4.29；95%CI = 1.06 - 17.4）是显著的独立预后因素。同时，无病生存（DFS）分析显示，ypT≥3（HR = 5.52；95%CI = 1.15 - 26.6）和ypN≥1（HR = 7.74；95%CI = 1.58 - 37.9）是独立预后因素。此外，PLNs中高FOXP3状态与低DFS率相关，尽管该关联无统计学意义（HR = 1.70；95%CI = 0.58 - 5.02）。