Glitzky Shirrell, Franzen Achim, Coordes Annekatrin
Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Centre Ruppin Brandenburg (UKRB), Brandenburg Medical School, Neuruppin, Germany.
Faculty of Health Sciences Brandenburg, Joint Faculty of the University of Potsdam, Brandenburg University of Technology Cottbus-Senftenberg and Brandenburg Medical School, Potsdam, Germany.
Anticancer Res. 2025 Feb;45(2):709-718. doi: 10.21873/anticanres.17459.
BACKGROUND/AIM: Decreasing numbers of tonsillectomies (TE) and an increasing frequency of oropharyngeal squamous cell carcinoma (OPSCC) is a well-known finding in western societies. A retrospective cohort study was performed to investigate the association between a history of TE and the development of OPSCC.
This study included all OPSCC patients who were treated between 2004 and 2023 at the Department of Otorhinolaryngology in University Medical Centre Ruppin Brandenburg in Germany. Digital patient charts were used to collect patient information.
Of the 320 patients with OPSCC, 19 (5.9%) had a history of TE. In 63.2% of cases, the procedure was performed in childhood, and 36.8% in adulthood. Our results indicate significant differences in terms of tumor location between the patients with and without a history of TE (p=0.010). In patients without TE, OPSCC was localized in the tonsillar region (45%), in the base of the tongue (29%), and other regions (26%). In patients with a history of TE the frequency was 16%, 63%, and 21%, respectively. Age at initial diagnosis, initial tumor size, p16/HPV status, residual tumor, venous and lymphatic extracapsular extension, recurrence, and alcohol abuse significantly influenced overall survival without any difference between the two groups.
A history of TE is associated with a decreased risk of tumor localization in the tonsillar region, especially when TE was performed in adulthood. Additionally, in patients with OPSCC and a history of TE, the tumor is more frequently localized at the base of the tongue. A history of TE does not affect demographics, the outcomes of tumor parameters or the prognosis of our patients.
背景/目的：在西方社会，扁桃体切除术（TE）数量的减少和口咽鳞状细胞癌（OPSCC）发病率的增加是一个众所周知的现象。本研究进行了一项回顾性队列研究，以探讨TE病史与OPSCC发生之间的关联。
本研究纳入了2004年至2023年期间在德国鲁平勃兰登堡大学医学中心耳鼻喉科接受治疗的所有OPSCC患者。使用数字患者病历收集患者信息。
在320例OPSCC患者中，19例（5.9%）有TE病史。在63.2%的病例中，手术在儿童期进行，36.8%在成年期进行。我们的结果表明，有TE病史和无TE病史的患者在肿瘤位置方面存在显著差异（p = 0.010）。在无TE的患者中，OPSCC位于扁桃体区域（45%）、舌根（29%）和其他区域（26%）。有TE病史的患者中，相应频率分别为16%、63%和21%。初次诊断时的年龄、初始肿瘤大小、p16/人乳头瘤病毒状态、残留肿瘤、静脉和淋巴管外膜侵犯、复发以及酗酒对总生存率有显著影响，两组之间无差异。
TE病史与扁桃体区域肿瘤定位风险降低相关，尤其是在成年期进行TE手术时。此外，在有TE病史的OPSCC患者中，肿瘤更常位于舌根。TE病史不影响患者的人口统计学特征、肿瘤参数结果或预后。
