微小RNA在生殖细胞肿瘤诊断及临床管理中的当前作用
Current Role of MicroRNAs in the Diagnosis and Clinical Management of Germ Cell Tumors.
作者信息
Tavares Nuno Tiago, Henrique Rui, Jerónimo Carmen, Lobo João
机构信息
Cancer Biology and Epigenetics Group, IPO Porto Research Center (GEBC CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (P.CCC) & CI-IPOP@RISE (Health Research Network), IPO Porto, Research Center, CI-LAB3, 1st Floor, F Building. Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal; Doctoral Programme in Biomedical Sciences, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Rua Jorge Viterbo Ferreira 228, Porto 4050-513, Portugal.
Cancer Biology and Epigenetics Group, IPO Porto Research Center (GEBC CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (P.CCC) & CI-IPOP@RISE (Health Research Network), IPO Porto, Research Center, CI-LAB3, 1st Floor, F Building. Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal; Department of Pathology and Molecular Immunology, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Rua Jorge Viterbo Ferreira 228, Porto 4050-513, Portugal; Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (P.CCC), R. Dr. António Bernardino de Almeida, Porto 4200-072, Portugal.
出版信息
Surg Pathol Clin. 2025 Mar;18(1):91-100. doi: 10.1016/j.path.2024.08.003. Epub 2024 Dec 3.
Germ cell tumors (GCTs) are a rare and heterogeneous group of neoplasms arising from primitive germ cells. MicroRNAs are small noncoding RNAs that have emerged as potential cancer biomarkers in the last decade. In particular, miR-371a-3p has shown good diagnostic performance for germ cell neoplasia in situ-derived testicular GCTs in several well-established cohorts and is expected to enter the clinical arena in the near future. GCTs universally exhibit high expression of miR-371-373 and miR-302/367 clusters and low expression of let-7 family miRNAs. Further studies are needed to assess the potential role of these miRNAs as biomarkers of ovarian and extragonadal GCTs.
生殖细胞肿瘤（GCTs）是一组罕见且异质性的肿瘤，起源于原始生殖细胞。微小RNA是一类小的非编码RNA，在过去十年中已成为潜在的癌症生物标志物。特别是，miR-371a-3p在几个成熟的队列研究中对原位生殖细胞肿瘤衍生的睾丸GCTs显示出良好的诊断性能，预计在不久的将来进入临床应用。GCTs普遍表现出miR-371-373和miR-302/367簇的高表达以及let-7家族微小RNA的低表达。需要进一步研究来评估这些微小RNA作为卵巢和性腺外GCTs生物标志物的潜在作用。
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