Tavares Nuno Tiago, Henrique Rui, Jerónimo Carmen, Lobo João
Cancer Biology and Epigenetics Group, IPO Porto Research Center (GEBC CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (P.CCC) & CI-IPOP@RISE (Health Research Network), IPO Porto, Research Center, CI-LAB3, 1st Floor, F Building. Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal; Doctoral Programme in Biomedical Sciences, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Rua Jorge Viterbo Ferreira 228, Porto 4050-513, Portugal.
Cancer Biology and Epigenetics Group, IPO Porto Research Center (GEBC CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (P.CCC) & CI-IPOP@RISE (Health Research Network), IPO Porto, Research Center, CI-LAB3, 1st Floor, F Building. Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal; Department of Pathology and Molecular Immunology, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Rua Jorge Viterbo Ferreira 228, Porto 4050-513, Portugal; Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (P.CCC), R. Dr. António Bernardino de Almeida, Porto 4200-072, Portugal.
Surg Pathol Clin. 2025 Mar;18(1):91-100. doi: 10.1016/j.path.2024.08.003. Epub 2024 Dec 3.
Germ cell tumors (GCTs) are a rare and heterogeneous group of neoplasms arising from primitive germ cells. MicroRNAs are small noncoding RNAs that have emerged as potential cancer biomarkers in the last decade. In particular, miR-371a-3p has shown good diagnostic performance for germ cell neoplasia in situ-derived testicular GCTs in several well-established cohorts and is expected to enter the clinical arena in the near future. GCTs universally exhibit high expression of miR-371-373 and miR-302/367 clusters and low expression of let-7 family miRNAs. Further studies are needed to assess the potential role of these miRNAs as biomarkers of ovarian and extragonadal GCTs.
生殖细胞肿瘤（GCTs）是一组罕见且异质性的肿瘤，起源于原始生殖细胞。微小RNA是一类小的非编码RNA，在过去十年中已成为潜在的癌症生物标志物。特别是，miR-371a-3p在几个成熟的队列研究中对原位生殖细胞肿瘤衍生的睾丸GCTs显示出良好的诊断性能，预计在不久的将来进入临床应用。GCTs普遍表现出miR-371-373和miR-302/367簇的高表达以及let-7家族微小RNA的低表达。需要进一步研究来评估这些微小RNA作为卵巢和性腺外GCTs生物标志物的潜在作用。
