在新辅助全身治疗后，HER2阴性残留乳腺癌患者改用曲妥珠单抗-美坦新偶联物（T-DM1）是否仍合理？
Is switching to T-DM1 still justified in HER2-negative residual breast cancer after neoadjuvant systemic therapy?
作者信息
Tjalma Wiebren, Teuwen Laure-Anne, Altintas Sevilay, Papadimitriou Konstantinos
机构信息
Multidisciplinary Breast Clinic, Antwerp University Hospital, Drie Eikenstraat 655, 2650 Edegem, Belgium; Faculty of Medicine, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.
Multidisciplinary Breast Clinic, Antwerp University Hospital, Drie Eikenstraat 655, 2650 Edegem, Belgium; Faculty of Medicine, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.
出版信息
Breast. 2025 Jun;81:103885. doi: 10.1016/j.breast.2025.103885. Epub 2025 Jan 21.
Abstract
The standard of care for HER2-positive and hormone receptor-positive breast cancer patients who receive neoadjuvant chemotherapy (NACT) combined with trastuzumab, with or without pertuzumab, is to continue with adjuvant T-DM1 in cases of an incomplete response according to KATHERINE trial results. However, the optimal management for patients with residual disease with loss of HER2 expression is not widely studied. Loss of HER2 expression after NACT with anti HER2 is a rarer event with questionable value both as a predictive prognostic marker.
摘要
对于接受新辅助化疗（NACT）联合曲妥珠单抗（无论是否联合帕妥珠单抗）的HER2阳性和激素受体阳性乳腺癌患者，根据KATHERINE试验结果，治疗标准是在反应不完全的情况下继续使用辅助性曲妥珠单抗偶联物（T-DM1）。然而，对于HER2表达缺失的残留病患者的最佳管理方法尚未得到广泛研究。使用抗HER2药物进行新辅助化疗后HER2表达缺失是一种较罕见的情况，作为预测性预后标志物，其价值存疑。
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本文引用的文献
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