Davis Charles K, Jeong Soomin, Subramanian Shruti, Choi Jeongwoo, Ostrom Carlie M, Park Sena, Vemuganti Raghu
Department of Neurological Surgery, University of Wisconsin, 600 Highland Ave, Madison, WI, USA.
Neuroscience Training Program, University of Wisconsin, Madison, WI, USA.
Neuromolecular Med. 2025 Jan 31;27(1):13. doi: 10.1007/s12017-025-08835-3.
Transcription of > 50% of the mammalian coding genes follows circadian rhythm in an organ-specific manner. Recent findings highlighted the influence of time of the day in the progression of various neurological diseases and therapies. In the present study, we evaluated the effect of time of occurrence of traumatic brain injury (TBI) on behavioral and neuropathological outcomes in mice of both sexes. Following a controlled cortical impact injury induced between Zeitgeber time (ZT)1-4 or ZT13-16, behavioral deficits and brain damage were evaluated. There were no significant differences in post-TBI motor function between groups ZT1-4 and ZT13-16 in either male or female mice compared with the sex-matched naïve control. TBI-induced anxiety-like behavior was significantly higher in the female ZT13-16 cohort compared to the naïve cohort; but, no difference was observed between injured groups in both sexes. Similarly, spatial learning and memory were not significantly different between the ZT1-4 and ZT13-16 groups in both sexes. Post-TBI cortical lesion volume was also not significantly different between ZT1-4 and ZT-13-16 groups in both sexes. The present study observed no significant effects of occurrence time on TBI-induced brain damage or behavioral deficits in male and female mice.
超过50%的哺乳动物编码基因的转录以器官特异性方式遵循昼夜节律。最近的研究结果突出了一天中的时间对各种神经系统疾病进展和治疗的影响。在本研究中，我们评估了创伤性脑损伤（TBI）发生时间对雌雄小鼠行为和神经病理学结果的影响。在 Zeitgeber 时间（ZT）1 - 4 或 ZT13 - 16 之间诱导可控皮质撞击损伤后，评估行为缺陷和脑损伤情况。与性别匹配的未受伤对照组相比，ZT1 - 4组和ZT13 - 16组的雄性或雌性小鼠在TBI后的运动功能上均无显著差异。与未受伤组相比，ZT13 - 16组的雌性小鼠中TBI诱导的焦虑样行为显著更高；但在两性的受伤组之间未观察到差异。同样，ZT1 - 4组和ZT13 - 16组在两性的空间学习和记忆方面也无显著差异。ZT1 - 4组和ZT - 13 - 16组在两性的TBI后皮质损伤体积上也无显著差异。本研究观察到发生时间对雄性和雌性小鼠TBI诱导的脑损伤或行为缺陷没有显著影响。
