Huang Weiqiang, Jiang Tao, He Jiaxuan, Ruan Jing, Wu Baihui, Tao Runchao, Xu Peiye, Wang Yongpan, Chen Rongbing, Wang Hanbing, Yang Qinsi, Zhang Kun, Jin Libo, Sun Da, You Jinfeng
Department of General Surgery, The First People's Hospital of Jiashan, Jiashan Hospital Afliated of Jiaxing University, Jiaxing, 314100, China.
Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou, 325035, China.
Probiotics Antimicrob Proteins. 2025 Jun;17(3):1038-1063. doi: 10.1007/s12602-025-10471-z. Epub 2025 Jan 31.
Over the past 3 years, there has been a growing interest in clinical research regarding the potential involvement of intestinal flora in thyroid cancer (TC). This review delves into the intricate connection between intestinal flora and TC, focusing on the particular intestinal flora that is directly linked to the disease and identifying which may be able to predict potential microbial markers of TC. In order to shed light on the inflammatory pathways connected to the onset of TC, we investigated the impact of intestinal flora on immune modulation and the connection between chronic inflammation when investigating the role of intestinal flora in the pathogenesis of TC. Furthermore, the potential role of intestinal flora metabolites in the regulation of thyroid function was clarified by exploring the effects of short-chain fatty acids and lipopolysaccharide on thyroid hormone synthesis and metabolism. Based on these findings, we further explore the effects of probiotics, prebiotics, postbiotics, vitamins, and trace elements.
在过去3年里，肠道菌群在甲状腺癌（TC）中的潜在作用越来越受到临床研究的关注。本综述深入探讨了肠道菌群与TC之间的复杂联系，重点关注与该疾病直接相关的特定肠道菌群，并确定哪些菌群可能能够预测TC的潜在微生物标志物。为了阐明与TC发病相关的炎症途径，我们在研究肠道菌群在TC发病机制中的作用时，调查了肠道菌群对免疫调节的影响以及慢性炎症之间的联系。此外，通过探索短链脂肪酸和脂多糖对甲状腺激素合成和代谢的影响，阐明了肠道菌群代谢产物在甲状腺功能调节中的潜在作用。基于这些发现，我们进一步探讨了益生菌、益生元、后生元、维生素和微量元素的作用。
